Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervous system. Animals deficient in the complement com...

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Detalles Bibliográficos
Autores principales: Gytz Olesen, Heidi, Michailidou, Iliana, Zelek, Wioleta M., Vreijling, Jeroen, Ruizendaal, Patrick, de Klein, Ferry, Marquart, J. Arnoud, Kuipers, Thomas B., Mei, Hailiang, Zhang, Yuchun, Ahasan, Muhammad, Johnson, Krista K., Wang, Yi, Morgan, B. Paul, van Dijk, Marcus, Fluiter, Kees, Andersen, Gregers Rom, Baas, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643903/
https://www.ncbi.nlm.nih.gov/pubmed/35551129
http://dx.doi.org/10.1159/000524587

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