IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion

Although absence of interleukin-7 (IL-7) signaling completely abrogates T and B lymphopoiesis in mice, patients with severe combined immunodeficiency caused by mutations in the IL-7 receptor α chain (IL-7Rα) still generate peripheral blood B cells. Consequently, human B lymphopoiesis has been though...

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Detalles Bibliográficos
Autores principales: Kaiser, Fabian M. P., Janowska, Iga, Menafra, Roberta, de Gier, Melanie, Korzhenevich, Jakov, Pico-Knijnenburg, Ingrid, Khatri, Indu, Schulz, Ansgar, Kuijpers, Taco W., Lankester, Arjan C., Konstantinidis, Lukas, Erlacher, Miriam, Kloet, Susan, van Schouwenburg, Pauline A., Rizzi, Marta, van der Burg, Mirjam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Plenary Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644098/
https://www.ncbi.nlm.nih.gov/pubmed/37369082
http://dx.doi.org/10.1182/blood.2023019721

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