Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases

[Image: see text] Pathogenic free-living amoebae (pFLA) can cause life-threatening central nervous system (CNS) infections and warrant the investigation of new chemical agents to combat the rise of infection from these pathogens. Naegleria fowleri glucokinase (NfGlck), a key metabolic enzyme involve...

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Autores principales: Kassu, Mintesinot, Parvatkar, Prakash T., Milanes, Jillian, Monaghan, Neil P., Kim, Chungsik, Dowgiallo, Matthew, Zhao, Yingzhao, Asakawa, Ami H., Huang, Lili, Wagner, Alicia, Miller, Brandon, Carter, Karissa, Barrett, Kayleigh F., Tillery, Logan M., Barrett, Lynn K., Phan, Isabelle Q., Subramanian, Sandhya, Myler, Peter J., Van Voorhis, Wesley C., Leahy, James W., Rice, Christopher A., Kyle, Dennis E., Morris, James, Manetsch, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644346/
https://www.ncbi.nlm.nih.gov/pubmed/37820055
http://dx.doi.org/10.1021/acsinfecdis.3c00284

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