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MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density

BACKGROUND: Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from spontaneous deamination of 5’-methylcytosine. METHODS: Here, we have investigate...

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Detalles Bibliográficos
Autores principales:	Papin, Christophe, Ibrahim, Abdulkhaleg, Sabir, Jamal S. M., Le Gras, Stéphanie, Stoll, Isabelle, Albiheyri, Raed S., Zari, Ali T., Bahieldin, Ahmed, Bellacosa, Alfonso, Bronner, Christian, Hamiche, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644448/ https://www.ncbi.nlm.nih.gov/pubmed/37957685 http://dx.doi.org/10.1186/s13046-023-02882-z

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