CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

Pregnenolone (P5) is synthesized as the first bioactive steroid in the mitochondria from cholesterol. Clusters of differentiation 4 (CD4+) and Clusters of differentiation 8 (CD8+) immune cells synthesize P5 de novo; P5, in turn, play important role in immune homeostasis and regulation. However, P5’s...

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Detalles Bibliográficos
Autores principales: Roy, Sougata, Roy, Sudeep, Mahata, Bidesh, Pramanik, Jhuma, Hennrich, Marco L., Gavin, Anne-Claude, Teichmann, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644475/
https://www.ncbi.nlm.nih.gov/pubmed/38022565
http://dx.doi.org/10.3389/fimmu.2023.1229703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644475/
https://www.ncbi.nlm.nih.gov/pubmed/38022565
http://dx.doi.org/10.3389/fimmu.2023.1229703

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