Cargando…
Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis
Chronic pruritus (CP) is one of the most frequent symptoms among dermatological conditions, capable of reducing the quality of life (QoL). CP may be induced by atopic dermatitis or other dermatological and/or non-dermatological conditions. In this article, we report the case of a patient affected by...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644923/ https://www.ncbi.nlm.nih.gov/pubmed/37850777 http://dx.doi.org/10.23750/abm.v94i5.14279 |
_version_ | 1785147295288786944 |
---|---|
author | Paolino, Giovanni Di Nicola, Matteo Riccardo Marcatti, Magda Rizzo, Nathalie Bianchi, Vittoria Giulia Ferla, Valeria Mercuri, Santo Raffaele |
author_facet | Paolino, Giovanni Di Nicola, Matteo Riccardo Marcatti, Magda Rizzo, Nathalie Bianchi, Vittoria Giulia Ferla, Valeria Mercuri, Santo Raffaele |
author_sort | Paolino, Giovanni |
collection | PubMed |
description | Chronic pruritus (CP) is one of the most frequent symptoms among dermatological conditions, capable of reducing the quality of life (QoL). CP may be induced by atopic dermatitis or other dermatological and/or non-dermatological conditions. In this article, we report the case of a patient affected by generalized CP, characterised by multiple papulo-nodular and escoriatic lesions, developed after the onset of an immunoglobulin G (IgG) kappa monoclonal gammopathy of renal significance (MGRS), associated with renal insufficiency. Therefore, a combined treatment with dupilumab for CP and bortezomib for the hematologic malignancy was administered to the patient. The present case report highlights the efficacy of dupilumab for the treatment of CP. Moreover, no relevant side effects were recorded during the treatment in combination with other systemic biological drugs for other systemic pathologies. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-10644923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-106449232023-11-15 Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis Paolino, Giovanni Di Nicola, Matteo Riccardo Marcatti, Magda Rizzo, Nathalie Bianchi, Vittoria Giulia Ferla, Valeria Mercuri, Santo Raffaele Acta Biomed Case Report Chronic pruritus (CP) is one of the most frequent symptoms among dermatological conditions, capable of reducing the quality of life (QoL). CP may be induced by atopic dermatitis or other dermatological and/or non-dermatological conditions. In this article, we report the case of a patient affected by generalized CP, characterised by multiple papulo-nodular and escoriatic lesions, developed after the onset of an immunoglobulin G (IgG) kappa monoclonal gammopathy of renal significance (MGRS), associated with renal insufficiency. Therefore, a combined treatment with dupilumab for CP and bortezomib for the hematologic malignancy was administered to the patient. The present case report highlights the efficacy of dupilumab for the treatment of CP. Moreover, no relevant side effects were recorded during the treatment in combination with other systemic biological drugs for other systemic pathologies. (www.actabiomedica.it) Mattioli 1885 2023 2023-10-17 /pmc/articles/PMC10644923/ /pubmed/37850777 http://dx.doi.org/10.23750/abm.v94i5.14279 Text en Copyright: © 2023 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Case Report Paolino, Giovanni Di Nicola, Matteo Riccardo Marcatti, Magda Rizzo, Nathalie Bianchi, Vittoria Giulia Ferla, Valeria Mercuri, Santo Raffaele Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis |
title | Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis |
title_full | Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis |
title_fullStr | Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis |
title_full_unstemmed | Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis |
title_short | Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis |
title_sort | combination treatment of dupilumab with bortezomib in a patient with igg kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644923/ https://www.ncbi.nlm.nih.gov/pubmed/37850777 http://dx.doi.org/10.23750/abm.v94i5.14279 |
work_keys_str_mv | AT paolinogiovanni combinationtreatmentofdupilumabwithbortezomibinapatientwithiggkappagammopathyofrenalsignificanceuremicpruritusandchroniclichenoiddermatitis AT dinicolamatteoriccardo combinationtreatmentofdupilumabwithbortezomibinapatientwithiggkappagammopathyofrenalsignificanceuremicpruritusandchroniclichenoiddermatitis AT marcattimagda combinationtreatmentofdupilumabwithbortezomibinapatientwithiggkappagammopathyofrenalsignificanceuremicpruritusandchroniclichenoiddermatitis AT rizzonathalie combinationtreatmentofdupilumabwithbortezomibinapatientwithiggkappagammopathyofrenalsignificanceuremicpruritusandchroniclichenoiddermatitis AT bianchivittoriagiulia combinationtreatmentofdupilumabwithbortezomibinapatientwithiggkappagammopathyofrenalsignificanceuremicpruritusandchroniclichenoiddermatitis AT ferlavaleria combinationtreatmentofdupilumabwithbortezomibinapatientwithiggkappagammopathyofrenalsignificanceuremicpruritusandchroniclichenoiddermatitis AT mercurisantoraffaele combinationtreatmentofdupilumabwithbortezomibinapatientwithiggkappagammopathyofrenalsignificanceuremicpruritusandchroniclichenoiddermatitis |