Adipose-derived stromal vascular fraction (SVF for the treatment of androgenic alopecia (AGA): a systematic review

BACKGROUND AND AIM: Androgenetic alopecia (AGA) is a common chronic, hereditary, cutaneous, and androgen-dependent condition. Low self-esteem and negative impact on quality of life are often consequences of AGA. Clinical treatment of AGA using SVF (Stromal Vascular Fraction) has been effective. The hair follicle is affected by various environmental factors and one of the most important factors is the vascularity of the scalp which is itself affected by SVF. METHODS: In October 2022, we conducted a systematic review to identify all scientific publications discussing hair loss treatment with stromal vascular fraction or adipose stem cells. We selected 140 articles. After a screening process, we kept 9 articles complying with inclusion criteria. RESULTS: No serious adverse events were reported in all studies. Despite a standardized protocol was not found, all studies reported a statistically significant increase in the number (density) of hair after SVF treatment. Two studies found a significant improvement in the pull test. An increase in hair diameter was noticed after treatment. The combination of medical therapy and SVF proved to be advantageous. CONCLUSIONS: SVF is nowadays at the center of studies in the field of regenerative medicine due to its potential applications in many branches of medicine and surgery. The initial results are very promising but furthermore, studies are necessary to establish a methodical and systematic research capable of demonstrating its real benefits and the creation of homogenous treatment protocols. (www.actabiomedica.it)