Cargando…

Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile

At present, there is no gold standard to assess patient adherence to combination antiretroviral therapy (cART). Therefore, this study aimed to characterize the epidemiological profile, delineate adherence indicators, and identify factors associated with adherence and delays in obtaining medication i...

Descripción completa

Detalles Bibliográficos
Autores principales: Piegas, E.M., Ziolkowski, M.I., Bittencourt, R.A., Malheiros, C.K.C., Miranda, F.F., Dias, C.F., Mocellin, L.P., Haas, S.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644963/
https://www.ncbi.nlm.nih.gov/pubmed/37970919
http://dx.doi.org/10.1590/1414-431X2023e12738
_version_ 1785147301601214464
author Piegas, E.M.
Ziolkowski, M.I.
Bittencourt, R.A.
Malheiros, C.K.C.
Miranda, F.F.
Dias, C.F.
Mocellin, L.P.
Haas, S.E.
author_facet Piegas, E.M.
Ziolkowski, M.I.
Bittencourt, R.A.
Malheiros, C.K.C.
Miranda, F.F.
Dias, C.F.
Mocellin, L.P.
Haas, S.E.
author_sort Piegas, E.M.
collection PubMed
description At present, there is no gold standard to assess patient adherence to combination antiretroviral therapy (cART). Therefore, this study aimed to characterize the epidemiological profile, delineate adherence indicators, and identify factors associated with adherence and delays in obtaining medication in patients registered at the Specialized Assistance Service in HIV/AIDS in Brazil. This is a descriptive study based on secondary data obtained from official databases of the Brazilian Ministry of Health. Adherence and delay were measured by the frequency of cART medication acquisition in 24 months, and a multivariate linear regression model was developed to identify the factors associated with non-adherence and delays. In 50.2% of the subjects, the viral load remained undetectable throughout the study period. Only 12.4% of patients were fully adherent to cART. Regarding indicators, a value of 0.83 was found for adherence, 0.09 for delay in days, and 0.21 for the number of times the patient was late to obtain the medication. The multivariate analysis showed that males, age between 20 and 59 years, having not changed the cART, and the presence of ≥1000 HIV RNA copies/mL were predictive factors for adherence and delays (P≤0.01). We demonstrated that monitoring cART medication distribution is possible using health indicators, and identifying the factors associated with poor adherence to cART helps characterize patients at higher risks of unsuccessful therapy.
format Online
Article
Text
id pubmed-10644963
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Associação Brasileira de Divulgação Científica
record_format MEDLINE/PubMed
spelling pubmed-106449632023-11-13 Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile Piegas, E.M. Ziolkowski, M.I. Bittencourt, R.A. Malheiros, C.K.C. Miranda, F.F. Dias, C.F. Mocellin, L.P. Haas, S.E. Braz J Med Biol Res Research Article At present, there is no gold standard to assess patient adherence to combination antiretroviral therapy (cART). Therefore, this study aimed to characterize the epidemiological profile, delineate adherence indicators, and identify factors associated with adherence and delays in obtaining medication in patients registered at the Specialized Assistance Service in HIV/AIDS in Brazil. This is a descriptive study based on secondary data obtained from official databases of the Brazilian Ministry of Health. Adherence and delay were measured by the frequency of cART medication acquisition in 24 months, and a multivariate linear regression model was developed to identify the factors associated with non-adherence and delays. In 50.2% of the subjects, the viral load remained undetectable throughout the study period. Only 12.4% of patients were fully adherent to cART. Regarding indicators, a value of 0.83 was found for adherence, 0.09 for delay in days, and 0.21 for the number of times the patient was late to obtain the medication. The multivariate analysis showed that males, age between 20 and 59 years, having not changed the cART, and the presence of ≥1000 HIV RNA copies/mL were predictive factors for adherence and delays (P≤0.01). We demonstrated that monitoring cART medication distribution is possible using health indicators, and identifying the factors associated with poor adherence to cART helps characterize patients at higher risks of unsuccessful therapy. Associação Brasileira de Divulgação Científica 2023-11-13 /pmc/articles/PMC10644963/ /pubmed/37970919 http://dx.doi.org/10.1590/1414-431X2023e12738 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Piegas, E.M.
Ziolkowski, M.I.
Bittencourt, R.A.
Malheiros, C.K.C.
Miranda, F.F.
Dias, C.F.
Mocellin, L.P.
Haas, S.E.
Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile
title Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile
title_full Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile
title_fullStr Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile
title_full_unstemmed Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile
title_short Factors associated with adherence to antiretroviral therapy in HIV-infected subjects and the use of indicators to characterize the treatment adhesion profile
title_sort factors associated with adherence to antiretroviral therapy in hiv-infected subjects and the use of indicators to characterize the treatment adhesion profile
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644963/
https://www.ncbi.nlm.nih.gov/pubmed/37970919
http://dx.doi.org/10.1590/1414-431X2023e12738
work_keys_str_mv AT piegasem factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile
AT ziolkowskimi factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile
AT bittencourtra factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile
AT malheirosckc factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile
AT mirandaff factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile
AT diascf factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile
AT mocellinlp factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile
AT haasse factorsassociatedwithadherencetoantiretroviraltherapyinhivinfectedsubjectsandtheuseofindicatorstocharacterizethetreatmentadhesionprofile