ATP-responsive Mn(ii)-based T(1) contrast agent for MRI

A novel diacetylpyridylcarbohydrazide–DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn(2+)) arms (MnL(DPA-Zn)2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T(1) contrast applications. Compound 2 shows enhanced relaxivity (r(1) =...

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Detalles Bibliográficos
Autores principales: Anbu, Sellamuthu, Kenning, Lawerence, Stasiuk, Graeme J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644988/
https://www.ncbi.nlm.nih.gov/pubmed/37902503
http://dx.doi.org/10.1039/d3cc03430e
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author Anbu, Sellamuthu
Kenning, Lawerence
Stasiuk, Graeme J.
author_facet Anbu, Sellamuthu
Kenning, Lawerence
Stasiuk, Graeme J.
author_sort Anbu, Sellamuthu
collection PubMed
description A novel diacetylpyridylcarbohydrazide–DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn(2+)) arms (MnL(DPA-Zn)2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T(1) contrast applications. Compound 2 shows enhanced relaxivity (r(1) = 11.52 mM(−1) s(−1)) upon selective ATP binding over other phosphates.
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spelling pubmed-106449882023-11-15 ATP-responsive Mn(ii)-based T(1) contrast agent for MRI Anbu, Sellamuthu Kenning, Lawerence Stasiuk, Graeme J. Chem Commun (Camb) Chemistry A novel diacetylpyridylcarbohydrazide–DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn(2+)) arms (MnL(DPA-Zn)2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T(1) contrast applications. Compound 2 shows enhanced relaxivity (r(1) = 11.52 mM(−1) s(−1)) upon selective ATP binding over other phosphates. The Royal Society of Chemistry 2023-09-19 /pmc/articles/PMC10644988/ /pubmed/37902503 http://dx.doi.org/10.1039/d3cc03430e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Anbu, Sellamuthu
Kenning, Lawerence
Stasiuk, Graeme J.
ATP-responsive Mn(ii)-based T(1) contrast agent for MRI
title ATP-responsive Mn(ii)-based T(1) contrast agent for MRI
title_full ATP-responsive Mn(ii)-based T(1) contrast agent for MRI
title_fullStr ATP-responsive Mn(ii)-based T(1) contrast agent for MRI
title_full_unstemmed ATP-responsive Mn(ii)-based T(1) contrast agent for MRI
title_short ATP-responsive Mn(ii)-based T(1) contrast agent for MRI
title_sort atp-responsive mn(ii)-based t(1) contrast agent for mri
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644988/
https://www.ncbi.nlm.nih.gov/pubmed/37902503
http://dx.doi.org/10.1039/d3cc03430e
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AT kenninglawerence atpresponsivemniibasedt1contrastagentformri
AT stasiukgraemej atpresponsivemniibasedt1contrastagentformri

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