Cargando…

Multi-epitope vaccine candidates based on mycobacterial membrane protein large (MmpL) proteins against Mycobacterium ulcerans

Buruli ulcer (BU) is a neglected tropical disease. It is caused by the bacterium Mycobacterium ulcerans and is characterized by skin lesions. Several studies were performed testing the Bacillus Calmette-Guérin (BCG) vaccine in human and animal models and M. ulcerans-specific vaccines in animal model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ishwarlall, Tamara Z., Adeleke, Victoria T., Maharaj, Leah, Okpeku, Moses, Adeniyi, Adebayo A., Adeleke, Matthew A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645115/ https://www.ncbi.nlm.nih.gov/pubmed/37935359 http://dx.doi.org/10.1098/rsob.230330

Ejemplares similares

Identification of potential candidate vaccines against Mycobacterium ulcerans based on the major facilitator superfamily transporter protein
por: Ishwarlall, Tamara Z., et al.
Publicado: (2022)

Immunoinformatics prediction of overlapping CD8(+) T-cell, IFN-γ and IL-4 inducer CD4(+) T-cell and linear B-cell epitopes based vaccines against COVID-19 (SARS-CoV-2)
por: Fatoba, Abiodun J., et al.
Publicado: (2021)

Design of a Multiepitope Vaccine against Chicken Anemia Virus Disease
por: Fatoba, Abiodun Joseph, et al.
Publicado: (2022)

Screening of apical membrane antigen-1 (AMA1), dense granule protein-7 (GRA7) and rhoptry protein-16 (ROP16) antigens for a potential vaccine candidate against Toxoplasma gondii for chickens
por: Madlala, Thabile, et al.
Publicado: (2023)

Designing multiepitope-based vaccine against Eimeria from immune mapped protein 1 (IMP-1) antigen using immunoinformatic approach
por: Madlala, Thabile, et al.
Publicado: (2021)

Author Correction: Designing multiepitope-based vaccine against Eimeria from immune mapped protein 1 (IMP-1) antigen using immunoinformatic approach
por: Madlala, Thabile, et al.
Publicado: (2022)

Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors
por: McNeil, Matthew B., et al.
Publicado: (2020)

Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport
por: Su, Chih-Chia, et al.
Publicado: (2021)

Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis
por: Li, Ming, et al.
Publicado: (2020)

Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis
por: Yamamoto, Kentaro, et al.
Publicado: (2021)

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis
por: Grover, Shipra, et al.
Publicado: (2020)

MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
por: Melly, Geoff, et al.
Publicado: (2019)

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections
por: Li, Wei, et al.
Publicado: (2018)

MmpL3 Inhibition: A New Approach to Treat Nontuberculous Mycobacterial Infections
por: Sethiya, Jigar P., et al.
Publicado: (2020)

The driving force for mycolic acid export by mycobacterial MmpL3 is proton translocation
por: Parish, Tanya
Publicado: (2022)

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10
por: Ahmed, Mohamed, et al.
Publicado: (2022)

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption
por: Shetty, Annanya, et al.
Publicado: (2018)

In Silico Prediction of Epitopes in Virulence Proteins of Mycobacterium ulcerans for Vaccine Designing
por: Mohinani, Taruna, et al.
Publicado: (2021)

Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review
por: Roux, Alexandra T., et al.
Publicado: (2021)

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression
por: Degiacomi, Giulia, et al.
Publicado: (2017)

Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor
por: Berube, Bryan, et al.
Publicado: (2023)

Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor
por: Berube, Bryan, et al.
Publicado: (2023)

Molecular Mechanisms of MmpL3 Function and Inhibition
por: Williams, John T., et al.
Publicado: (2023)

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria
por: Fay, Allison, et al.
Publicado: (2019)

Proton transfer activity of the reconstituted Mycobacterium tuberculosis MmpL3 is modulated by substrate mimics and inhibitors
por: Stevens, Casey M., et al.
Publicado: (2022)

Whole Genome Sequencing Contributions and Challenges in Disease Reduction Focused on Malaria
por: Akoniyon, Olusegun Philip, et al.
Publicado: (2022)

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds
por: Li, Wei, et al.
Publicado: (2019)

Targeting MmpL3 for anti-tuberculosis drug development
por: Bolla, Jani R.
Publicado: (2020)

The application of machine learning to predict genetic relatedness using human mtDNA hypervariable region I sequences
por: Govender, Priyanka, et al.
Publicado: (2022)

Understanding the interactions between Eimeria infection and gut microbiota, towards the control of chicken coccidiosis: a review
por: Madlala, Thabile, et al.
Publicado: (2021)

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
por: Ray, Peter C., et al.
Publicado: (2021)

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
por: Varela, Cristian, et al.
Publicado: (2012)

Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
por: Li, Wei, et al.
Publicado: (2017)

Molecular Interactions Associated with Coagulation of Organic Pollutants by 2S Albumin of Plant Proteins: A Computational Approach
por: Adeleke, Victoria T., et al.
Publicado: (2022)

Subtractive Genomics Approach for Identification of Novel Therapeutic Drug Targets in Mycoplasma genitalium
por: Fatoba, Abiodun Joseph, et al.
Publicado: (2021)

Editorial: Genetics of Apicomplexans and Apicomplexan-Related Parasitic Diseases
por: Okpeku, Moses, et al.
Publicado: (2022)

Malaria diagnostic methods with the elimination goal in view
por: Oyegoke, Olukunle O., et al.
Publicado: (2022)

MmpS5-MmpL5 Transporters Provide Mycobacterium smegmatis Resistance to imidazo[1,2-b][1,2,4,5]tetrazines
por: Maslov, Dmitry A., et al.
Publicado: (2020)

In vivo imaging of MmpL transporters reveals distinct subcellular locations for export of mycolic acids and non-essential trehalose polyphleates in the mycobacterial outer membrane
por: Thouvenel, Laurie, et al.
Publicado: (2023)

Use of Soluble Extracellular Regions of MmpL (SERoM) as Vaccines for Tuberculosis
por: Strong, Emily J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5m87qirkq36oi69kv93g330f5v