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Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis
OBJECTIVE: Multiple sclerosis is an autoimmune disease that commonly affects the cervical part of the spinal cord. The aim of this study was to evaluate the relationship between cervical spinal cord atrophy and clinical disability in multiple sclerosis patients. METHODS: We examined the cervical spi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Associação Médica Brasileira
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645167/ https://www.ncbi.nlm.nih.gov/pubmed/37971136 http://dx.doi.org/10.1590/1806-9282.20230949 |
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author | Celik, Nihal Gurlek Karabulut, Ahmet Kagan Fazliogullari, Zeliha Gumus, Haluk Cebeci, Hakan Dogan, Nadire Unver |
author_facet | Celik, Nihal Gurlek Karabulut, Ahmet Kagan Fazliogullari, Zeliha Gumus, Haluk Cebeci, Hakan Dogan, Nadire Unver |
author_sort | Celik, Nihal Gurlek |
collection | PubMed |
description | OBJECTIVE: Multiple sclerosis is an autoimmune disease that commonly affects the cervical part of the spinal cord. The aim of this study was to evaluate the relationship between cervical spinal cord atrophy and clinical disability in multiple sclerosis patients. METHODS: We examined the cervical spinal cord area measurements of 64 multiple sclerosis patients and 64 healthy control groups over the images obtained by a T2-weighted magnetic resonance imaging device. RESULTS: The C2-3, C3-4, C4-5, and C6-7 axial cross-sectional surface area values of the patient group were statistically lower than those of the control group (p<0.05). A negative correlation was found between patients’ Expanded Disability Status Scale scores and C4-5, C5-6, and C6-7 axial area (axial area p<0.05; r1=-0.472, r2=-0.513, and r3=-0.415). CONCLUSION: When all parameters were evaluated, the data of our control group were found to be higher than the multiple sclerosis groups. There appears to be a significant relationship between patients with cervical spinal cord atrophy and an increase in Expanded Disability Status Scale scores. |
format | Online Article Text |
id | pubmed-10645167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Associação Médica Brasileira |
record_format | MEDLINE/PubMed |
spelling | pubmed-106451672023-11-13 Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis Celik, Nihal Gurlek Karabulut, Ahmet Kagan Fazliogullari, Zeliha Gumus, Haluk Cebeci, Hakan Dogan, Nadire Unver Rev Assoc Med Bras (1992) Original Article OBJECTIVE: Multiple sclerosis is an autoimmune disease that commonly affects the cervical part of the spinal cord. The aim of this study was to evaluate the relationship between cervical spinal cord atrophy and clinical disability in multiple sclerosis patients. METHODS: We examined the cervical spinal cord area measurements of 64 multiple sclerosis patients and 64 healthy control groups over the images obtained by a T2-weighted magnetic resonance imaging device. RESULTS: The C2-3, C3-4, C4-5, and C6-7 axial cross-sectional surface area values of the patient group were statistically lower than those of the control group (p<0.05). A negative correlation was found between patients’ Expanded Disability Status Scale scores and C4-5, C5-6, and C6-7 axial area (axial area p<0.05; r1=-0.472, r2=-0.513, and r3=-0.415). CONCLUSION: When all parameters were evaluated, the data of our control group were found to be higher than the multiple sclerosis groups. There appears to be a significant relationship between patients with cervical spinal cord atrophy and an increase in Expanded Disability Status Scale scores. Associação Médica Brasileira 2023-11-13 /pmc/articles/PMC10645167/ /pubmed/37971136 http://dx.doi.org/10.1590/1806-9282.20230949 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Celik, Nihal Gurlek Karabulut, Ahmet Kagan Fazliogullari, Zeliha Gumus, Haluk Cebeci, Hakan Dogan, Nadire Unver Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis |
title | Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis |
title_full | Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis |
title_fullStr | Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis |
title_full_unstemmed | Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis |
title_short | Relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis |
title_sort | relationship between cervical spinal cord morphometry and clinical disability in patients with multiple sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645167/ https://www.ncbi.nlm.nih.gov/pubmed/37971136 http://dx.doi.org/10.1590/1806-9282.20230949 |
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