An intravenous pancreatic cancer therapeutic: Characterization of CRISPR/Cas9n-modified Clostridium novyi-Non Toxic

Clostridium novyi has demonstrated selective efficacy against solid tumors largely due to the microenvironment contained within dense tumor cores. The core of a solid tumor is typically hypoxic, acidic, and necrotic—impeding the penetration of current therapeutics. C. novyi is attracted to the tumor...

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Detalles Bibliográficos
Autores principales: Dailey, Kaitlin M., Small, James M., Pullan, Jessica E., Winfree, Seth, Vance, Krysten E., Orr, Megan, Mallik, Sanku, Bayles, Kenneth W., Hollingsworth, Michael A., Brooks, Amanda E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645340/
https://www.ncbi.nlm.nih.gov/pubmed/37963142
http://dx.doi.org/10.1371/journal.pone.0289183

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