Intratumoral androgen biosynthesis associated with 3β-hydroxysteroid dehydrogenase 1 promotes resistance to radiotherapy in prostate cancer

Half of all men with advanced prostate cancer (PCa) inherit at least 1 copy of an adrenal-permissive HSD3B1 (1245C) allele, which increases levels of 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) and promotes intracellular androgen biosynthesis. Germline inheritance of the adrenally permissive allele c...

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Detalles Bibliográficos
Autores principales: Ganguly, Shinjini, Lone, Zaeem, Muskara, Andrew, Imamura, Jarrell, Hardaway, Aimalie, Patel, Mona, Berk, Mike, Smile, Timothy D., Davicioni, Elai, Stephans, Kevin L., Ciezki, Jay, Weight, Christopher J., Gupta, Shilpa, Reddy, Chandana A., Tendulkar, Rahul D., Chakraborty, Abhishek A., Klein, Eric A., Sharifi, Nima, Mian, Omar Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645386/
https://www.ncbi.nlm.nih.gov/pubmed/37966114
http://dx.doi.org/10.1172/JCI165718

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