FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in triple-negative breast cancer (TNBC) to identify subpopulations in...

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Detalles Bibliográficos
Autores principales: Li, Mengjiao, Nishimura, Tatsunori, Takeuchi, Yasuto, Hongu, Tsunaki, Wang, Yuming, Shiokawa, Daisuke, Wang, Kang, Hirose, Haruka, Sasahara, Asako, Yano, Masao, Ishikawa, Satoko, Inokuchi, Masafumi, Ota, Tetsuo, Tanabe, Masahiko, Tada, Kei-ichiro, Akiyama, Tetsu, Cheng, Xi, Liu, Chia-Chi, Yamashita, Toshinari, Sugano, Sumio, Uchida, Yutaro, Chiba, Tomoki, Asahara, Hiroshi, Nakagawa, Masahiro, Sato, Shinya, Miyagi, Yohei, Shimamura, Teppei, Nagai, Luis Augusto E., Kanai, Akinori, Katoh, Manami, Nomura, Seitaro, Nakato, Ryuichiro, Suzuki, Yutaka, Tojo, Arinobu, Voon, Dominic C., Ogawa, Seishi, Okamoto, Koji, Foukakis, Theodoros, Gotoh, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645391/
https://www.ncbi.nlm.nih.gov/pubmed/37966117
http://dx.doi.org/10.1172/JCI166666

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