The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer

Aberrant androgen receptor (AR) signaling drives prostate cancer (PC), and it is a key therapeutic target. Although initially effective, the generation of alternatively spliced AR variants (AR-Vs) compromises efficacy of treatments. In contrast to full-length AR (AR-FL), AR-Vs constitutively activat...

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Detalles Bibliográficos
Autores principales: Adamson, Beth, Brittain, Nicholas, Walker, Laura, Duncan, Ruaridh, Luzzi, Sara, Rescigno, Pasquale, Smith, Graham, McGill, Suzanne, Burchmore, Richard J.S., Willmore, Elaine, Hickson, Ian, Robson, Craig N., Bogdan, Denisa, Jimenez-Vacas, Juan M., Paschalis, Alec, Welti, Jonathan, Yuan, Wei, McCracken, Stuart R., Heer, Rakesh, Sharp, Adam, de Bono, Johann S., Gaughan, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645393/
https://www.ncbi.nlm.nih.gov/pubmed/37751307
http://dx.doi.org/10.1172/JCI169200

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