A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression

Monocytes and monocyte-derived macrophages (MDMs) from blood circulation infiltrate glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells induce the expression of the potent proinflammatory cytokine IL-1β in MDM, which engages IL-1R1 in tumor cells, activates the NF-κB pat...

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Detalles Bibliográficos
Autores principales: Chen, Zhihong, Giotti, Bruno, Kaluzova, Milota, Vallcorba, Montse Puigdelloses, Rawat, Kavita, Price, Gabrielle, Herting, Cameron J., Pinero, Gonzalo, Cristea, Simona, Ross, James L., Ackley, James, Maximov, Victor, Szulzewsky, Frank, Thomason, Wes, Marquez-Ropero, Mar, Angione, Angelo, Nichols, Noah, Tsankova, Nadejda M., Michor, Franziska, Shayakhmetov, Dmitry M., Gutmann, David H., Tsankov, Alexander M., Hambardzumyan, Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645395/
https://www.ncbi.nlm.nih.gov/pubmed/37733448
http://dx.doi.org/10.1172/JCI163802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645395/
https://www.ncbi.nlm.nih.gov/pubmed/37733448
http://dx.doi.org/10.1172/JCI163802

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