Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

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Homeodomain transcription factors (HD TFs) are instrumental to vertebrate development. Mutations in HD TFs have been linked to human diseases, but their pathogenic mechanisms remain elusive. Here, we use Cone-Rod Homeobox (CRX) as a model to decipher the disease-causing mechanisms of two HD mutation...

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Detalles Bibliográficos
Autores principales: Zheng, Yiqiao, Sun, Chi, Zhang, Xiaodong, Ruzycki, Philip A, Chen, Shiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645426/
https://www.ncbi.nlm.nih.gov/pubmed/37963072
http://dx.doi.org/10.7554/eLife.87147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645426/
https://www.ncbi.nlm.nih.gov/pubmed/37963072
http://dx.doi.org/10.7554/eLife.87147

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