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Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer

Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of...

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Autores principales: Supuramanian, Sathammai Sathappa, Dsa, Sid, Harihar, Sitaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645471/
https://www.ncbi.nlm.nih.gov/pubmed/37970212
http://dx.doi.org/10.37349/etat.2023.00173
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author Supuramanian, Sathammai Sathappa
Dsa, Sid
Harihar, Sitaram
author_facet Supuramanian, Sathammai Sathappa
Dsa, Sid
Harihar, Sitaram
author_sort Supuramanian, Sathammai Sathappa
collection PubMed
description Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of cancer cells. They suppress the metastasis process by inhibiting colonization and by inducing dormancy. These genes function by regulating various cellular processes in the tumor microenvironment (TME), such as cell adhesion, invasion, migration, and angiogenesis. Dysregulation of metastasis suppressor genes can lead to the acquisition of an invasive and metastatic phenotype and lead to poor prognostic outcomes. The components of the TME generally play a necessary in the metastasis progression of tumor cells. This review has identified and elaborated on the role of a few metastatic suppressors associated with the TME that have been shown to inhibit metastasis in BC by different mechanisms, such as blocking certain cell signaling molecules involved in cancer cell migration, invasion, enhancing immune surveillance of cancer cells, and promoting the formation of a protective extracellular matrix (ECM). Understanding the interaction of metastatic suppressor genes and the components of TME has important implications for the development of novel therapeutic strategies to target the metastatic cascade. Targeting these genes or their downstream signaling pathways offers a promising approach to inhibiting the spread of cancer cells and improves patient outcomes.
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spelling pubmed-106454712023-11-15 Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer Supuramanian, Sathammai Sathappa Dsa, Sid Harihar, Sitaram Explor Target Antitumor Ther Review Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of cancer cells. They suppress the metastasis process by inhibiting colonization and by inducing dormancy. These genes function by regulating various cellular processes in the tumor microenvironment (TME), such as cell adhesion, invasion, migration, and angiogenesis. Dysregulation of metastasis suppressor genes can lead to the acquisition of an invasive and metastatic phenotype and lead to poor prognostic outcomes. The components of the TME generally play a necessary in the metastasis progression of tumor cells. This review has identified and elaborated on the role of a few metastatic suppressors associated with the TME that have been shown to inhibit metastasis in BC by different mechanisms, such as blocking certain cell signaling molecules involved in cancer cell migration, invasion, enhancing immune surveillance of cancer cells, and promoting the formation of a protective extracellular matrix (ECM). Understanding the interaction of metastatic suppressor genes and the components of TME has important implications for the development of novel therapeutic strategies to target the metastatic cascade. Targeting these genes or their downstream signaling pathways offers a promising approach to inhibiting the spread of cancer cells and improves patient outcomes. Open Exploration Publishing 2023 2023-10-11 /pmc/articles/PMC10645471/ /pubmed/37970212 http://dx.doi.org/10.37349/etat.2023.00173 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Supuramanian, Sathammai Sathappa
Dsa, Sid
Harihar, Sitaram
Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
title Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
title_full Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
title_fullStr Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
title_full_unstemmed Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
title_short Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
title_sort molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645471/
https://www.ncbi.nlm.nih.gov/pubmed/37970212
http://dx.doi.org/10.37349/etat.2023.00173
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