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Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Open Exploration Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645471/ https://www.ncbi.nlm.nih.gov/pubmed/37970212 http://dx.doi.org/10.37349/etat.2023.00173 |
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author | Supuramanian, Sathammai Sathappa Dsa, Sid Harihar, Sitaram |
author_facet | Supuramanian, Sathammai Sathappa Dsa, Sid Harihar, Sitaram |
author_sort | Supuramanian, Sathammai Sathappa |
collection | PubMed |
description | Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of cancer cells. They suppress the metastasis process by inhibiting colonization and by inducing dormancy. These genes function by regulating various cellular processes in the tumor microenvironment (TME), such as cell adhesion, invasion, migration, and angiogenesis. Dysregulation of metastasis suppressor genes can lead to the acquisition of an invasive and metastatic phenotype and lead to poor prognostic outcomes. The components of the TME generally play a necessary in the metastasis progression of tumor cells. This review has identified and elaborated on the role of a few metastatic suppressors associated with the TME that have been shown to inhibit metastasis in BC by different mechanisms, such as blocking certain cell signaling molecules involved in cancer cell migration, invasion, enhancing immune surveillance of cancer cells, and promoting the formation of a protective extracellular matrix (ECM). Understanding the interaction of metastatic suppressor genes and the components of TME has important implications for the development of novel therapeutic strategies to target the metastatic cascade. Targeting these genes or their downstream signaling pathways offers a promising approach to inhibiting the spread of cancer cells and improves patient outcomes. |
format | Online Article Text |
id | pubmed-10645471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Open Exploration Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-106454712023-11-15 Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer Supuramanian, Sathammai Sathappa Dsa, Sid Harihar, Sitaram Explor Target Antitumor Ther Review Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of cancer cells. They suppress the metastasis process by inhibiting colonization and by inducing dormancy. These genes function by regulating various cellular processes in the tumor microenvironment (TME), such as cell adhesion, invasion, migration, and angiogenesis. Dysregulation of metastasis suppressor genes can lead to the acquisition of an invasive and metastatic phenotype and lead to poor prognostic outcomes. The components of the TME generally play a necessary in the metastasis progression of tumor cells. This review has identified and elaborated on the role of a few metastatic suppressors associated with the TME that have been shown to inhibit metastasis in BC by different mechanisms, such as blocking certain cell signaling molecules involved in cancer cell migration, invasion, enhancing immune surveillance of cancer cells, and promoting the formation of a protective extracellular matrix (ECM). Understanding the interaction of metastatic suppressor genes and the components of TME has important implications for the development of novel therapeutic strategies to target the metastatic cascade. Targeting these genes or their downstream signaling pathways offers a promising approach to inhibiting the spread of cancer cells and improves patient outcomes. Open Exploration Publishing 2023 2023-10-11 /pmc/articles/PMC10645471/ /pubmed/37970212 http://dx.doi.org/10.37349/etat.2023.00173 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Supuramanian, Sathammai Sathappa Dsa, Sid Harihar, Sitaram Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
title | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
title_full | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
title_fullStr | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
title_full_unstemmed | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
title_short | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
title_sort | molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645471/ https://www.ncbi.nlm.nih.gov/pubmed/37970212 http://dx.doi.org/10.37349/etat.2023.00173 |
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