Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15

Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous dietary component, determines the transcription level of the...

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Detalles Bibliográficos
Autores principales: Van, Nguyen T., Zhang, Karen, Wigmore, Rachel M., Kennedy, Anne I., DaSilva, Carolina R., Huang, Jialing, Ambelil, Manju, Villagomez, Jose H., O’Connor, Gerald J., Longman, Randy S., Cao, Miao, Snook, Adam E., Platten, Michael, Kasenty, Gerard, Sigal, Luis J., Prendergast, George C., Kim, Sangwon V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645889/
https://www.ncbi.nlm.nih.gov/pubmed/37963876
http://dx.doi.org/10.1038/s41467-023-43211-4

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