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Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation

The purpose of this research is to examine the correlation between blood urea nitrogen (BUN) and severe abdominal aortic calcification (AAC) among American adults aged 40 years and older. A total of 2757 participants in the NHANES from 2013 to 2014 were included in the final analysis. BUN was measur...

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Autores principales: Xue, Kun, Xing, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645972/
https://www.ncbi.nlm.nih.gov/pubmed/37964009
http://dx.doi.org/10.1038/s41598-023-47109-5
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author Xue, Kun
Xing, Shanshan
author_facet Xue, Kun
Xing, Shanshan
author_sort Xue, Kun
collection PubMed
description The purpose of this research is to examine the correlation between blood urea nitrogen (BUN) and severe abdominal aortic calcification (AAC) among American adults aged 40 years and older. A total of 2757 participants in the NHANES from 2013 to 2014 were included in the final analysis. BUN was measured by means of the enzymatic conductivity rate method. AAC scores were quantified by the Kauppila scoring system, and severe AAC was defined as an AAC score ≥ 6. Multivariable logistic regression and restricted cubic splines were used in the analyses. In the multivariable logistic regression model, the highest BUN level (log 2-transformed) was associated with an increased risk of severe AAC [odds ratio (OR) = 1.77, 95% CI 1.17, 2.71]. The restricted cubic spline plot displayed a reverse l-shaped association between BUN (log2-transformed) and severe AAC (p for nonlinearity < 0.001). In addition,the interactions of BUN were not discover. In general, there is a positive correlation between BUN and the risk of severe AAC.
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spelling pubmed-106459722023-11-13 Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation Xue, Kun Xing, Shanshan Sci Rep Article The purpose of this research is to examine the correlation between blood urea nitrogen (BUN) and severe abdominal aortic calcification (AAC) among American adults aged 40 years and older. A total of 2757 participants in the NHANES from 2013 to 2014 were included in the final analysis. BUN was measured by means of the enzymatic conductivity rate method. AAC scores were quantified by the Kauppila scoring system, and severe AAC was defined as an AAC score ≥ 6. Multivariable logistic regression and restricted cubic splines were used in the analyses. In the multivariable logistic regression model, the highest BUN level (log 2-transformed) was associated with an increased risk of severe AAC [odds ratio (OR) = 1.77, 95% CI 1.17, 2.71]. The restricted cubic spline plot displayed a reverse l-shaped association between BUN (log2-transformed) and severe AAC (p for nonlinearity < 0.001). In addition,the interactions of BUN were not discover. In general, there is a positive correlation between BUN and the risk of severe AAC. Nature Publishing Group UK 2023-11-13 /pmc/articles/PMC10645972/ /pubmed/37964009 http://dx.doi.org/10.1038/s41598-023-47109-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Xue, Kun
Xing, Shanshan
Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation
title Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation
title_full Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation
title_fullStr Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation
title_full_unstemmed Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation
title_short Blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation
title_sort blood urea nitrogen concentration is associated with severe abdominal aortic calcification in adults: a cross-sectional investigation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645972/
https://www.ncbi.nlm.nih.gov/pubmed/37964009
http://dx.doi.org/10.1038/s41598-023-47109-5
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