Cargando…

Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists

Peroxisome proliferator-activated receptor-γ (PPAR-γ) partial agonists or antagonists, also termed as selective PPAR-γ modulators, are more beneficial than full agonists because they can avoid the adverse effects associated with PPAR-γ full agonists, such as weight gain and congestive heart disorder...

Descripción completa

Detalles Bibliográficos
Autores principales:	Najmi, Asim, Alam, Md Shamsher, Thangavel, Neelaveni, Taha, Manal M. E., Meraya, Abdulkarim M., Albratty, Mohammed, Alhazmi, Hassan A., Ahsan, Waquar, Haque, Anzarul, Azam, Faizul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645977/ https://www.ncbi.nlm.nih.gov/pubmed/37963936 http://dx.doi.org/10.1038/s41598-023-47157-x

Ejemplares similares

Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs
por: Thangavel, Neelaveni, et al.
Publicado: (2017)

Perception of Individuals with Diabetes about Efficacy and Safety of Complementary and Alternative Medicines (CAM) in the Jazan Region, Saudi Arabia
por: Meraya, Abdulkarim M., et al.
Publicado: (2022)

Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes
por: Yasmin, Sabina, et al.
Publicado: (2017)

Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19
por: Alhazmi, Hassan A., et al.
Publicado: (2021)

Alkaloidal Phytoconstituents for Diabetes Management: Exploring the Unrevealed Potential
por: Behl, Tapan, et al.
Publicado: (2022)

Pharmacophore model-aided virtual screening combined with comparative molecular docking and molecular dynamics for identification of marine natural products as SARS-CoV-2 papain-like protease inhibitors
por: Thangavel, Neelaveni, et al.
Publicado: (2022)

Benchmarked molecular docking integrated molecular dynamics stability analysis for prediction of SARS-CoV-2 papain-like protease inhibition by olive secoiridoids
por: Thangavel, Neelaveni, et al.
Publicado: (2023)

The Current Landscape of Bioactive Molecules against DENV: A Systematic Review
por: Babbar, Ritchu, et al.
Publicado: (2023)

Post-vaccination survey for monitoring the side effects associated with COVID-19 vaccines among healthcare professionals of Jazan province, Saudi Arabia
por: Ahsan, Waquar, et al.
Publicado: (2021)

Chalcone Scaffolds Exhibiting Acetylcholinesterase Enzyme Inhibition: Mechanistic and Computational Investigations
por: Malik, Yossra A., et al.
Publicado: (2022)

Heavy Metal Contamination in Leafy Vegetables Grown in Jazan Region of Saudi Arabia: Assessment of Possible Human Health Hazards
por: Najmi, Asim, et al.
Publicado: (2023)

Discovery Potent of Thiazolidinedione Derivatives as Antioxidant, α-Amylase Inhibitor, and Antidiabetic Agent
por: Sameeh, Manal Y., et al.
Publicado: (2021)

Reviving the mutual impact of SARS-COV-2 and obesity on patients: From morbidity to mortality
por: Behl, Tapan, et al.
Publicado: (2022)

Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends
por: Behl, Tapan, et al.
Publicado: (2022)

Effects of Thiazolidinedione and New Antidiabetic Agents on Stroke
por: Ahn, Chang Ho, et al.
Publicado: (2019)

Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules
por: Mohan, Syam, et al.
Publicado: (2020)

Structural Complementarity of Bruton’s Tyrosine Kinase and Its Inhibitors for Implication in B-Cell Malignancies and Autoimmune Diseases
por: Najmi, Asim, et al.
Publicado: (2023)

Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
por: Behl, Tapan, et al.
Publicado: (2022)

Molecular docking studies of 1-(substituted phenyl)-3-(naphtha [1, 2-d] thiazol-2-yl) urea/thiourea derivatives with human adenosine A(2A) receptor
por: Azam, Faizul, et al.
Publicado: (2011)

Thiazolidinediones on PPARγ: The Roles in Bone Remodeling
por: Wei, Wei, et al.
Publicado: (2011)

Understanding the role of "sunshine vitamin D" in Parkinson’s disease: A review
por: Behl, Tapan, et al.
Publicado: (2022)

Hypoglycemic and Hypolipidemic Swords: Synthesis and In-vivo Biological Assessment of 5-benzylidene-2,4-thiazolidinediones
por: Patil, Vijay, et al.
Publicado: (2021)

Effect of Drying Temperature on Physical, Chemical, and Antioxidant Properties of Ginger Oil Loaded Gelatin-Sodium Alginate Edible Films
por: Al-Harrasi, Ahmed, et al.
Publicado: (2022)

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis
por: Lecka-Czernik, Beata
Publicado: (2010)

Design and evaluation of sustained release mucoadhesive film of sumatriptan succinate containing grafted co-polymer as the platform
por: Verma, Surajpal, et al.
Publicado: (2022)

Deciphering the Roles of Thiazolidinediones and PPARγ in Bladder Cancer
por: Chiu, Melody, et al.
Publicado: (2017)

Gallic Acid Crosslinked Gelatin and Casein Based Composite Films for Food Packaging Applications
por: Bhatia, Saurabh, et al.
Publicado: (2022)

Study of influence of Catha edulis (Khat) chewing on oral pharmacokinetics of irbesartan in rats using a newly developed HPLC-UV method
por: Alhazmi, Hassan A., et al.
Publicado: (2022)

Spectral analysis and antibacterial potential of bioactive principles of Sargassum crassifolium J. Agardh from Red sea of Jazan origin
por: Albratty, Mohammed, et al.
Publicado: (2021)

PPAR-γ Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain Tumors
por: Lichtor, Terry, et al.
Publicado: (2008)

Discovery of Novel Thiazolidinedione-Derivatives with Multi-Modal Antidiabetic Activities In Vitro and In Silico
por: Arineitwe, Charles, et al.
Publicado: (2023)

Molecular Docking and Molecular Dynamics Aided Virtual Search of OliveNet™ Directory for Secoiridoids to Combat SARS-CoV-2 Infection and Associated Hyperinflammatory Responses
por: Thangavel, Neelaveni, et al.
Publicado: (2021)

Microsecond MD Simulations to Explore the Structural and Energetic Differences between the Human RXRα-PPARγ vs. RXRα-PPARγ-DNA
por: Azam, Faizul, et al.
Publicado: (2022)

Exploration of Multiverse Activities of Endocannabinoids in Biological Systems
por: Behl, Tapan, et al.
Publicado: (2022)

Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective
por: Behl, Tapan, et al.
Publicado: (2022)

Virosome: An engineered virus for vaccine delivery
por: Ali, Hasan, et al.
Publicado: (2023)

Recent Advancements in the Diagnosis, Prevention, and Prospective Drug Therapy of COVID-19
por: Ahsan, Waquar, et al.
Publicado: (2020)

Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease
por: Behl, Tapan, et al.
Publicado: (2022)

Exploration of Cytotoxic Potential of Longifolene/Junipene Isolated from Chrysopogon zizanioides
por: Grover, Madhuri, et al.
Publicado: (2022)

Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones
por: Lu, Min, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_0f3m30tijcsilv9bf4pshcll74