Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma

BACKGROUND: Neuroblastoma is a paediatric cancer that is characterised by poor prognosis for chemoresistant disease, highlighting the need for better treatment options. Here, we asked whether BH3-mimetics inhibiting BCL2 proteins may eliminate chemoresistant neuroblastoma cells. METHODS: We utilised...

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Detalles Bibliográficos
Autores principales: Jacob, Maureen, Wiedemann, Sara, Brücher, Daniela, Pieper, Nadja M., Birkhold, Moni, Särchen, Vinzenz, Jeroch, Jan, Demes, Melanie C., Gretser, Steffen, Braun, Yannick, Gradhand, Elise, Rothweiler, Florian, Michaelis, Martin, Cinatl, Jindrich, Vogler, Meike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646009/
https://www.ncbi.nlm.nih.gov/pubmed/37723317
http://dx.doi.org/10.1038/s41416-023-02430-8

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