Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes

We report on single-molecule nanopore sensing combined with position-encoded DNA molecular probes, with chemistry tuned to simultaneously identify various antigen proteins and multiple RNA gene fragments of SARS-CoV-2 with high sensitivity and selectivity. We show that this sensing strategy can dire...

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Detalles Bibliográficos
Autores principales: Ren, Ren, Cai, Shenglin, Fang, Xiaona, Wang, Xiaoyi, Zhang, Zheng, Damiani, Micol, Hudlerova, Charlotte, Rosa, Annachiara, Hope, Joshua, Cook, Nicola J., Gorelkin, Peter, Erofeev, Alexander, Novak, Pavel, Badhan, Anjna, Crone, Michael, Freemont, Paul, Taylor, Graham P., Tang, Longhua, Edwards, Christopher, Shevchuk, Andrew, Cherepanov, Peter, Luo, Zhaofeng, Tan, Weihong, Korchev, Yuri, Ivanov, Aleksandar P., Edel, Joshua B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646045/
https://www.ncbi.nlm.nih.gov/pubmed/37963924
http://dx.doi.org/10.1038/s41467-023-43004-9

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