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Multisensory input modulates memory-guided spatial navigation in humans

Efficient navigation is supported by a cognitive map of space. The hippocampus plays a key role for this map by linking multimodal sensory information with spatial memory representations. However, in human navigation studies, the full range of sensory information is often unavailable due to the stat...

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Autores principales: Iggena, Deetje, Jeung, Sein, Maier, Patrizia M., Ploner, Christoph J., Gramann, Klaus, Finke, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646091/
https://www.ncbi.nlm.nih.gov/pubmed/37963986
http://dx.doi.org/10.1038/s42003-023-05522-6
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author Iggena, Deetje
Jeung, Sein
Maier, Patrizia M.
Ploner, Christoph J.
Gramann, Klaus
Finke, Carsten
author_facet Iggena, Deetje
Jeung, Sein
Maier, Patrizia M.
Ploner, Christoph J.
Gramann, Klaus
Finke, Carsten
author_sort Iggena, Deetje
collection PubMed
description Efficient navigation is supported by a cognitive map of space. The hippocampus plays a key role for this map by linking multimodal sensory information with spatial memory representations. However, in human navigation studies, the full range of sensory information is often unavailable due to the stationarity of experimental setups. We investigated the contribution of multisensory information to memory-guided spatial navigation by presenting a virtual version of the Morris water maze on a screen and in an immersive mobile virtual reality setup. Patients with hippocampal lesions and matched controls navigated to memorized object locations in relation to surrounding landmarks. Our results show that availability of multisensory input improves memory-guided spatial navigation in both groups. It has distinct effects on navigational behaviour, with greater improvement in spatial memory performance in patients. We conclude that congruent multisensory information shifts computations to extrahippocampal areas that support spatial navigation and compensates for spatial navigation deficits.
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spelling pubmed-106460912023-11-14 Multisensory input modulates memory-guided spatial navigation in humans Iggena, Deetje Jeung, Sein Maier, Patrizia M. Ploner, Christoph J. Gramann, Klaus Finke, Carsten Commun Biol Article Efficient navigation is supported by a cognitive map of space. The hippocampus plays a key role for this map by linking multimodal sensory information with spatial memory representations. However, in human navigation studies, the full range of sensory information is often unavailable due to the stationarity of experimental setups. We investigated the contribution of multisensory information to memory-guided spatial navigation by presenting a virtual version of the Morris water maze on a screen and in an immersive mobile virtual reality setup. Patients with hippocampal lesions and matched controls navigated to memorized object locations in relation to surrounding landmarks. Our results show that availability of multisensory input improves memory-guided spatial navigation in both groups. It has distinct effects on navigational behaviour, with greater improvement in spatial memory performance in patients. We conclude that congruent multisensory information shifts computations to extrahippocampal areas that support spatial navigation and compensates for spatial navigation deficits. Nature Publishing Group UK 2023-11-14 /pmc/articles/PMC10646091/ /pubmed/37963986 http://dx.doi.org/10.1038/s42003-023-05522-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Iggena, Deetje
Jeung, Sein
Maier, Patrizia M.
Ploner, Christoph J.
Gramann, Klaus
Finke, Carsten
Multisensory input modulates memory-guided spatial navigation in humans
title Multisensory input modulates memory-guided spatial navigation in humans
title_full Multisensory input modulates memory-guided spatial navigation in humans
title_fullStr Multisensory input modulates memory-guided spatial navigation in humans
title_full_unstemmed Multisensory input modulates memory-guided spatial navigation in humans
title_short Multisensory input modulates memory-guided spatial navigation in humans
title_sort multisensory input modulates memory-guided spatial navigation in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646091/
https://www.ncbi.nlm.nih.gov/pubmed/37963986
http://dx.doi.org/10.1038/s42003-023-05522-6
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