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The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade

The occurrence and progression of tumors are inseparable from glucose metabolism. With the development of tumors, the volume increases gradually and the nutritional supply of tumors cannot be fully guaranteed. The tumor microenvironment changes and glucose deficiency becomes the common stress enviro...

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Autores principales: Cui, Yingnan, Sun, Yuanlin, Li, Dongming, Zhang, Yuzheng, Zhang, Yangyu, Cao, Donghui, Cao, Xueyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646288/
https://www.ncbi.nlm.nih.gov/pubmed/38020920
http://dx.doi.org/10.3389/fcell.2023.1275543
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author Cui, Yingnan
Sun, Yuanlin
Li, Dongming
Zhang, Yuzheng
Zhang, Yangyu
Cao, Donghui
Cao, Xueyuan
author_facet Cui, Yingnan
Sun, Yuanlin
Li, Dongming
Zhang, Yuzheng
Zhang, Yangyu
Cao, Donghui
Cao, Xueyuan
author_sort Cui, Yingnan
collection PubMed
description The occurrence and progression of tumors are inseparable from glucose metabolism. With the development of tumors, the volume increases gradually and the nutritional supply of tumors cannot be fully guaranteed. The tumor microenvironment changes and glucose deficiency becomes the common stress environment of tumors. Here, we discuss the mutual influences between glucose deprivation and other features of the tumor microenvironment, such as hypoxia, immune escape, low pH, and oxidative stress. In the face of a series of stress responses brought by glucose deficiency, different types of tumors have different coping mechanisms. We summarize the tumor studies on glucose deficiency in the last decade and review the genes and pathways that determine the fate of tumors under harsh conditions. It turns out that most of these genes help tumor cells survive in glucose-deprivation conditions. The development of related inhibitors may bring new opportunities for the treatment of tumors.
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spelling pubmed-106462882023-01-01 The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade Cui, Yingnan Sun, Yuanlin Li, Dongming Zhang, Yuzheng Zhang, Yangyu Cao, Donghui Cao, Xueyuan Front Cell Dev Biol Cell and Developmental Biology The occurrence and progression of tumors are inseparable from glucose metabolism. With the development of tumors, the volume increases gradually and the nutritional supply of tumors cannot be fully guaranteed. The tumor microenvironment changes and glucose deficiency becomes the common stress environment of tumors. Here, we discuss the mutual influences between glucose deprivation and other features of the tumor microenvironment, such as hypoxia, immune escape, low pH, and oxidative stress. In the face of a series of stress responses brought by glucose deficiency, different types of tumors have different coping mechanisms. We summarize the tumor studies on glucose deficiency in the last decade and review the genes and pathways that determine the fate of tumors under harsh conditions. It turns out that most of these genes help tumor cells survive in glucose-deprivation conditions. The development of related inhibitors may bring new opportunities for the treatment of tumors. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646288/ /pubmed/38020920 http://dx.doi.org/10.3389/fcell.2023.1275543 Text en Copyright © 2023 Cui, Sun, Li, Zhang, Zhang, Cao and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Cui, Yingnan
Sun, Yuanlin
Li, Dongming
Zhang, Yuzheng
Zhang, Yangyu
Cao, Donghui
Cao, Xueyuan
The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade
title The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade
title_full The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade
title_fullStr The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade
title_full_unstemmed The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade
title_short The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade
title_sort crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646288/
https://www.ncbi.nlm.nih.gov/pubmed/38020920
http://dx.doi.org/10.3389/fcell.2023.1275543
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