Cargando…

Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation

Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Bioma...

Descripción completa

Detalles Bibliográficos
Autores principales: Sang, Jing, Ye, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646301/
https://www.ncbi.nlm.nih.gov/pubmed/38022658
http://dx.doi.org/10.3389/fimmu.2023.1268331
_version_ 1785134867396165632
author Sang, Jing
Ye, Xin
author_facet Sang, Jing
Ye, Xin
author_sort Sang, Jing
collection PubMed
description Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Biomarkers can offer insights into the patient’s immune response and outcomes, such as local tumor control, recurrence, overall survival, and progression-free survival. Identifying and validating such biomarkers can significantly impact clinical decision-making, leading to personalized treatment strategies and improved patient outcomes. This review provides a comprehensive overview of the current state of research on potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation, including their potential role in lung cancer management, and the challenges and future directions.
format Online
Article
Text
id pubmed-10646301
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106463012023-01-01 Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation Sang, Jing Ye, Xin Front Immunol Immunology Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Biomarkers can offer insights into the patient’s immune response and outcomes, such as local tumor control, recurrence, overall survival, and progression-free survival. Identifying and validating such biomarkers can significantly impact clinical decision-making, leading to personalized treatment strategies and improved patient outcomes. This review provides a comprehensive overview of the current state of research on potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation, including their potential role in lung cancer management, and the challenges and future directions. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646301/ /pubmed/38022658 http://dx.doi.org/10.3389/fimmu.2023.1268331 Text en Copyright © 2023 Sang and Ye https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sang, Jing
Ye, Xin
Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
title Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
title_full Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
title_fullStr Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
title_full_unstemmed Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
title_short Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
title_sort potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646301/
https://www.ncbi.nlm.nih.gov/pubmed/38022658
http://dx.doi.org/10.3389/fimmu.2023.1268331
work_keys_str_mv AT sangjing potentialbiomarkersforpredictingimmuneresponseandoutcomesinlungcancerpatientsundergoingthermalablation
AT yexin potentialbiomarkersforpredictingimmuneresponseandoutcomesinlungcancerpatientsundergoingthermalablation