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Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation
Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Bioma...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646301/ https://www.ncbi.nlm.nih.gov/pubmed/38022658 http://dx.doi.org/10.3389/fimmu.2023.1268331 |
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author | Sang, Jing Ye, Xin |
author_facet | Sang, Jing Ye, Xin |
author_sort | Sang, Jing |
collection | PubMed |
description | Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Biomarkers can offer insights into the patient’s immune response and outcomes, such as local tumor control, recurrence, overall survival, and progression-free survival. Identifying and validating such biomarkers can significantly impact clinical decision-making, leading to personalized treatment strategies and improved patient outcomes. This review provides a comprehensive overview of the current state of research on potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation, including their potential role in lung cancer management, and the challenges and future directions. |
format | Online Article Text |
id | pubmed-10646301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106463012023-01-01 Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation Sang, Jing Ye, Xin Front Immunol Immunology Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Biomarkers can offer insights into the patient’s immune response and outcomes, such as local tumor control, recurrence, overall survival, and progression-free survival. Identifying and validating such biomarkers can significantly impact clinical decision-making, leading to personalized treatment strategies and improved patient outcomes. This review provides a comprehensive overview of the current state of research on potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation, including their potential role in lung cancer management, and the challenges and future directions. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646301/ /pubmed/38022658 http://dx.doi.org/10.3389/fimmu.2023.1268331 Text en Copyright © 2023 Sang and Ye https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Sang, Jing Ye, Xin Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation |
title | Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation |
title_full | Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation |
title_fullStr | Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation |
title_full_unstemmed | Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation |
title_short | Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation |
title_sort | potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646301/ https://www.ncbi.nlm.nih.gov/pubmed/38022658 http://dx.doi.org/10.3389/fimmu.2023.1268331 |
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