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Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution

The objective of this research was to characterize the chemical composition of ethanolic extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria antarctica, their antioxidant activity, and enzymatic inhibition through in vitro and molecular docking analysis. In...

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Autores principales: Torres-Benítez, Alfredo, Ortega-Valencia, José Erick, Jara-Pinuer, Nicolás, Sanchez, Marta, Vargas-Arana, Gabriel, Gómez-Serranillos, María Pilar, Simirgiotis, Mario J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646315/
https://www.ncbi.nlm.nih.gov/pubmed/38026927
http://dx.doi.org/10.3389/fphar.2023.1251856
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author Torres-Benítez, Alfredo
Ortega-Valencia, José Erick
Jara-Pinuer, Nicolás
Sanchez, Marta
Vargas-Arana, Gabriel
Gómez-Serranillos, María Pilar
Simirgiotis, Mario J.
author_facet Torres-Benítez, Alfredo
Ortega-Valencia, José Erick
Jara-Pinuer, Nicolás
Sanchez, Marta
Vargas-Arana, Gabriel
Gómez-Serranillos, María Pilar
Simirgiotis, Mario J.
author_sort Torres-Benítez, Alfredo
collection PubMed
description The objective of this research was to characterize the chemical composition of ethanolic extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria antarctica, their antioxidant activity, and enzymatic inhibition through in vitro and molecular docking analysis. In total phenol content, FRAP, ORAC, and DPPH assays, the extracts showed significant antioxidant activity, and in in vitro assays for the inhibition of pancreatic lipase, α-glucosidase, and α-amylase enzymes, together with in silico studies for the prediction of pharmacokinetic properties, toxicity risks, and intermolecular interactions of compounds, the extracts evidenced inhibitory potential. A total of 13 compounds were identified by UHPLC-ESI-QTOF-MS in P. contortuplicata, 18 compounds in O. frigida, and 12 compounds in U. antarctica. This study contributes to the knowledge of the pool of bioactive compounds present in lichens of temperate and polar distribution and biological characteristics that increase interest in the discovery of natural products that offer alternatives for treatment studies of diseases related to oxidative stress and metabolic syndrome.
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spelling pubmed-106463152023-11-01 Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution Torres-Benítez, Alfredo Ortega-Valencia, José Erick Jara-Pinuer, Nicolás Sanchez, Marta Vargas-Arana, Gabriel Gómez-Serranillos, María Pilar Simirgiotis, Mario J. Front Pharmacol Pharmacology The objective of this research was to characterize the chemical composition of ethanolic extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria antarctica, their antioxidant activity, and enzymatic inhibition through in vitro and molecular docking analysis. In total phenol content, FRAP, ORAC, and DPPH assays, the extracts showed significant antioxidant activity, and in in vitro assays for the inhibition of pancreatic lipase, α-glucosidase, and α-amylase enzymes, together with in silico studies for the prediction of pharmacokinetic properties, toxicity risks, and intermolecular interactions of compounds, the extracts evidenced inhibitory potential. A total of 13 compounds were identified by UHPLC-ESI-QTOF-MS in P. contortuplicata, 18 compounds in O. frigida, and 12 compounds in U. antarctica. This study contributes to the knowledge of the pool of bioactive compounds present in lichens of temperate and polar distribution and biological characteristics that increase interest in the discovery of natural products that offer alternatives for treatment studies of diseases related to oxidative stress and metabolic syndrome. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646315/ /pubmed/38026927 http://dx.doi.org/10.3389/fphar.2023.1251856 Text en Copyright © 2023 Torres-Benítez, Ortega-Valencia, Jara-Pinuer, Sanchez, Vargas-Arana, Gómez-Serranillos and Simirgiotis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Torres-Benítez, Alfredo
Ortega-Valencia, José Erick
Jara-Pinuer, Nicolás
Sanchez, Marta
Vargas-Arana, Gabriel
Gómez-Serranillos, María Pilar
Simirgiotis, Mario J.
Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
title Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
title_full Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
title_fullStr Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
title_full_unstemmed Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
title_short Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
title_sort antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646315/
https://www.ncbi.nlm.nih.gov/pubmed/38026927
http://dx.doi.org/10.3389/fphar.2023.1251856
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