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Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial

Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical appli...

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Detalles Bibliográficos
Autores principales: Zhao, Meiping, Huang, Meili, Li, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646323/
https://www.ncbi.nlm.nih.gov/pubmed/38026866
http://dx.doi.org/10.3389/fbioe.2023.1292149
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author Zhao, Meiping
Huang, Meili
Li, Zhen
author_facet Zhao, Meiping
Huang, Meili
Li, Zhen
author_sort Zhao, Meiping
collection PubMed
description Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical application has yet to be realized. Current research is primarily focused on carrier-based delivery systems for lysozyme. In this review, we discuss four delivery systems that can be employed for lysozyme in wound healing treatment, specifically hydrogels, nanofilms, electrospun fibrous membranes, and modified-lysozyme composite systems. These systems not only enhance the stability of lysozyme but also enable its controlled and sustained release at wound sites, potentially overcoming some of the challenges associated with its direct application. Lastly, we delve into the perspectives and challenges related to the use of these delivery systems, hoping to spur further research and innovation in this promising field.
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spelling pubmed-106463232023-01-01 Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial Zhao, Meiping Huang, Meili Li, Zhen Front Bioeng Biotechnol Bioengineering and Biotechnology Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical application has yet to be realized. Current research is primarily focused on carrier-based delivery systems for lysozyme. In this review, we discuss four delivery systems that can be employed for lysozyme in wound healing treatment, specifically hydrogels, nanofilms, electrospun fibrous membranes, and modified-lysozyme composite systems. These systems not only enhance the stability of lysozyme but also enable its controlled and sustained release at wound sites, potentially overcoming some of the challenges associated with its direct application. Lastly, we delve into the perspectives and challenges related to the use of these delivery systems, hoping to spur further research and innovation in this promising field. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646323/ /pubmed/38026866 http://dx.doi.org/10.3389/fbioe.2023.1292149 Text en Copyright © 2023 Zhao, Huang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zhao, Meiping
Huang, Meili
Li, Zhen
Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
title Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
title_full Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
title_fullStr Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
title_full_unstemmed Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
title_short Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
title_sort exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646323/
https://www.ncbi.nlm.nih.gov/pubmed/38026866
http://dx.doi.org/10.3389/fbioe.2023.1292149
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