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Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical appli...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646323/ https://www.ncbi.nlm.nih.gov/pubmed/38026866 http://dx.doi.org/10.3389/fbioe.2023.1292149 |
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author | Zhao, Meiping Huang, Meili Li, Zhen |
author_facet | Zhao, Meiping Huang, Meili Li, Zhen |
author_sort | Zhao, Meiping |
collection | PubMed |
description | Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical application has yet to be realized. Current research is primarily focused on carrier-based delivery systems for lysozyme. In this review, we discuss four delivery systems that can be employed for lysozyme in wound healing treatment, specifically hydrogels, nanofilms, electrospun fibrous membranes, and modified-lysozyme composite systems. These systems not only enhance the stability of lysozyme but also enable its controlled and sustained release at wound sites, potentially overcoming some of the challenges associated with its direct application. Lastly, we delve into the perspectives and challenges related to the use of these delivery systems, hoping to spur further research and innovation in this promising field. |
format | Online Article Text |
id | pubmed-10646323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106463232023-01-01 Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial Zhao, Meiping Huang, Meili Li, Zhen Front Bioeng Biotechnol Bioengineering and Biotechnology Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical application has yet to be realized. Current research is primarily focused on carrier-based delivery systems for lysozyme. In this review, we discuss four delivery systems that can be employed for lysozyme in wound healing treatment, specifically hydrogels, nanofilms, electrospun fibrous membranes, and modified-lysozyme composite systems. These systems not only enhance the stability of lysozyme but also enable its controlled and sustained release at wound sites, potentially overcoming some of the challenges associated with its direct application. Lastly, we delve into the perspectives and challenges related to the use of these delivery systems, hoping to spur further research and innovation in this promising field. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646323/ /pubmed/38026866 http://dx.doi.org/10.3389/fbioe.2023.1292149 Text en Copyright © 2023 Zhao, Huang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Zhao, Meiping Huang, Meili Li, Zhen Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
title | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
title_full | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
title_fullStr | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
title_full_unstemmed | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
title_short | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
title_sort | exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646323/ https://www.ncbi.nlm.nih.gov/pubmed/38026866 http://dx.doi.org/10.3389/fbioe.2023.1292149 |
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