Cargando…

Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis

The development of disease screening methods using biomedical detection dogs relies on the collection and analysis of body odors, particularly volatile organic compounds (VOCs) present in body fluids. To capture and analyze odors produced by the human body, numerous protocols and materials are used...

Descripción completa

Detalles Bibliográficos
Autores principales: Maidodou, Laetitia, Clarot, Igor, Leemans, Michelle, Fromantin, Isabelle, Marchioni, Eric, Steyer, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646374/
https://www.ncbi.nlm.nih.gov/pubmed/38025078
http://dx.doi.org/10.3389/fchem.2023.1282450
_version_ 1785134884038115328
author Maidodou, Laetitia
Clarot, Igor
Leemans, Michelle
Fromantin, Isabelle
Marchioni, Eric
Steyer, Damien
author_facet Maidodou, Laetitia
Clarot, Igor
Leemans, Michelle
Fromantin, Isabelle
Marchioni, Eric
Steyer, Damien
author_sort Maidodou, Laetitia
collection PubMed
description The development of disease screening methods using biomedical detection dogs relies on the collection and analysis of body odors, particularly volatile organic compounds (VOCs) present in body fluids. To capture and analyze odors produced by the human body, numerous protocols and materials are used in forensics or medical studies. This paper provides an overview of sampling devices used to collect VOCs from sweat and exhaled air, for medical diagnostic purposes using canine olfaction and/or Gas Chromatography-Mass spectrometry (GC-MS). Canine olfaction and GC-MS are regarded as complementary tools, holding immense promise for detecting cancers and infectious diseases. However, existing literature lacks guidelines for selecting materials suitable for both canine olfaction and GC-MS. Hence, this review aims to address this gap and pave the way for efficient body odor sampling materials. The first section of the paper describes the materials utilized in training sniffing dogs, while the second section delves into the details of sampling devices and extraction techniques employed for exhaled air and sweat analysis using GC-MS. Finally, the paper proposes the development of an ideal sampling device tailored for detection purposes in the field of odorology. By bridging the knowledge gap, this study seeks to advance disease detection methodologies, harnessing the unique abilities of both dogs and GC-MS analysis in biomedical research.
format Online
Article
Text
id pubmed-10646374
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106463742023-01-01 Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis Maidodou, Laetitia Clarot, Igor Leemans, Michelle Fromantin, Isabelle Marchioni, Eric Steyer, Damien Front Chem Chemistry The development of disease screening methods using biomedical detection dogs relies on the collection and analysis of body odors, particularly volatile organic compounds (VOCs) present in body fluids. To capture and analyze odors produced by the human body, numerous protocols and materials are used in forensics or medical studies. This paper provides an overview of sampling devices used to collect VOCs from sweat and exhaled air, for medical diagnostic purposes using canine olfaction and/or Gas Chromatography-Mass spectrometry (GC-MS). Canine olfaction and GC-MS are regarded as complementary tools, holding immense promise for detecting cancers and infectious diseases. However, existing literature lacks guidelines for selecting materials suitable for both canine olfaction and GC-MS. Hence, this review aims to address this gap and pave the way for efficient body odor sampling materials. The first section of the paper describes the materials utilized in training sniffing dogs, while the second section delves into the details of sampling devices and extraction techniques employed for exhaled air and sweat analysis using GC-MS. Finally, the paper proposes the development of an ideal sampling device tailored for detection purposes in the field of odorology. By bridging the knowledge gap, this study seeks to advance disease detection methodologies, harnessing the unique abilities of both dogs and GC-MS analysis in biomedical research. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646374/ /pubmed/38025078 http://dx.doi.org/10.3389/fchem.2023.1282450 Text en Copyright © 2023 Maidodou, Clarot, Leemans, Fromantin, Marchioni and Steyer. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Maidodou, Laetitia
Clarot, Igor
Leemans, Michelle
Fromantin, Isabelle
Marchioni, Eric
Steyer, Damien
Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis
title Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis
title_full Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis
title_fullStr Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis
title_full_unstemmed Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis
title_short Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis
title_sort unraveling the potential of breath and sweat voc capture devices for human disease detection: a systematic-like review of canine olfaction and gc-ms analysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646374/
https://www.ncbi.nlm.nih.gov/pubmed/38025078
http://dx.doi.org/10.3389/fchem.2023.1282450
work_keys_str_mv AT maidodoulaetitia unravelingthepotentialofbreathandsweatvoccapturedevicesforhumandiseasedetectionasystematiclikereviewofcanineolfactionandgcmsanalysis
AT clarotigor unravelingthepotentialofbreathandsweatvoccapturedevicesforhumandiseasedetectionasystematiclikereviewofcanineolfactionandgcmsanalysis
AT leemansmichelle unravelingthepotentialofbreathandsweatvoccapturedevicesforhumandiseasedetectionasystematiclikereviewofcanineolfactionandgcmsanalysis
AT fromantinisabelle unravelingthepotentialofbreathandsweatvoccapturedevicesforhumandiseasedetectionasystematiclikereviewofcanineolfactionandgcmsanalysis
AT marchionieric unravelingthepotentialofbreathandsweatvoccapturedevicesforhumandiseasedetectionasystematiclikereviewofcanineolfactionandgcmsanalysis
AT steyerdamien unravelingthepotentialofbreathandsweatvoccapturedevicesforhumandiseasedetectionasystematiclikereviewofcanineolfactionandgcmsanalysis