Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens

Background: Early life stress (ELS) is a major risk factor for depression in adolescents. The nucleus accumbens (NAc) is a key center of the reward system, and spine remodeling in the NAc contributes to the development of depression. The Si-Ni-San formula (SNS) is a fundamental prescription for trea...

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Detalles Bibliográficos
Autores principales: Ye, Lihong, Wu, Jiayi, Liu, Zuyi, Deng, Di, Bai, Shasha, Yang, Lei, Xuan, Yao, Liu, Zehao, Shi, Yafei, Liu, Zhongqiu, Zhang, Rong, Zhao, Jinlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646421/
https://www.ncbi.nlm.nih.gov/pubmed/38026979
http://dx.doi.org/10.3389/fphar.2023.1274121

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