Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma

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Multiple large-scale genomic profiling efforts have been undertaken in osteosarcoma to define the genomic drivers of tumorigenesis, therapeutic response, and disease recurrence. The spatial and temporal intratumor heterogeneity could also play a role in promoting tumor growth and treatment resistanc...

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Detalles Bibliográficos
Autores principales: Kinnaman, Michael D., Zaccaria, Simone, Makohon-Moore, Alvin, Arnold, Brian, Levine, Max F., Gundem, Gunes, Arango Ossa, Juan E., Glodzik, Dominik, Rodríguez-Sánchez, M. Irene, Bouvier, Nancy, Li, Shanita, Stockfisch, Emily, Dunigan, Marisa, Cobbs, Cassidy, Bhanot, Umesh K., You, Daoqi, Mullen, Katelyn, Melchor, Jerry P., Ortiz, Michael V., O'Donohue, Tara J., Slotkin, Emily K., Wexler, Leonard H., Dela Cruz, Filemon S., Hameed, Meera R., Glade Bender, Julia L., Tap, William D., Meyers, Paul A., Papaemmanuil, Elli, Kung, Andrew L., Iacobuzio-Donahue, Christine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646480/
https://www.ncbi.nlm.nih.gov/pubmed/37812025
http://dx.doi.org/10.1158/0008-5472.CAN-23-0385
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