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Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study
BACKGROUND: This study aimed to investigate the clinical characteristics of gastric cancer (GC) patients with dermatomyositis (DM) and summarize the perioperative outcomes. METHODS: The clinical and pathological data of five patients diagnosed with co-occurring DM and GC (DM-GC group) were retrospec...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646486/ https://www.ncbi.nlm.nih.gov/pubmed/38026488 http://dx.doi.org/10.3389/fsurg.2023.1276575 |
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author | Aimaiti, Muerzhate Zhang, Haoyu Aikebaier, Dilidaer Ni, Bo Yin, Hanlin Dong, Zhongyi Zhang, Yeqi Guan, Yujing Bai, Long Wang, Shuchang Xia, Xiang Zhang, Zizhen |
author_facet | Aimaiti, Muerzhate Zhang, Haoyu Aikebaier, Dilidaer Ni, Bo Yin, Hanlin Dong, Zhongyi Zhang, Yeqi Guan, Yujing Bai, Long Wang, Shuchang Xia, Xiang Zhang, Zizhen |
author_sort | Aimaiti, Muerzhate |
collection | PubMed |
description | BACKGROUND: This study aimed to investigate the clinical characteristics of gastric cancer (GC) patients with dermatomyositis (DM) and summarize the perioperative outcomes. METHODS: The clinical and pathological data of five patients diagnosed with co-occurring DM and GC (DM-GC group) were retrospectively analyzed, who were admitted to the Department of Gastrointestinal Surgery at Ren ji Hospital, Shanghai Jiao Tong University, between January 2012 and April 2023. Their data were compared with 618 GC patients (GC-1 group) from September 2016 to August 2017 and 35 GC patients who were meticulously screened from 14,580 GC cases from January 2012 and April 2023. The matching criteria included identical gender, age, tumor location, TNM stage, and surgical procedure (7 GC patients were matched for each DM-GC patient). RESULTS: Analysis indicated that the DM-GC group comprised four female and one male patient. The female proportion was significantly higher (P = 0.032) than that of GC-1 group. In DM-GC group, four DM patients were diagnosed as GC within 12 months. One DM patients was diagnosed as GC within 15 months. Among them, four patients presented with varying degrees of skin rashes, muscle weakness while one patient had elevated CK levels as the typical symptom. Similarly, the preoperative tumor markers (CA-199 and CA-125) in the DM-GC group were significantly higher than normal levels (CA-199: 100 vs. 28.6%, P = 0.002; CA-125: 40 vs. 2.9%, P = 0.003) compared to GC-2 group. Moreover, postoperative complication incidence and the length of hospital stay were significantly higher in the DM-GC than GC-2 group [complication rate: 40 vs. 8.6%, P = 0.047; hospital stay: 15 days (range: 9–28) vs. 9 days (range: 8–10), P = 0.021]. CONCLUSION: GC Patients with dermatomyositis are more prone to experience postoperative complications and longer hospital stay. |
format | Online Article Text |
id | pubmed-10646486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106464862023-11-01 Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study Aimaiti, Muerzhate Zhang, Haoyu Aikebaier, Dilidaer Ni, Bo Yin, Hanlin Dong, Zhongyi Zhang, Yeqi Guan, Yujing Bai, Long Wang, Shuchang Xia, Xiang Zhang, Zizhen Front Surg Surgery BACKGROUND: This study aimed to investigate the clinical characteristics of gastric cancer (GC) patients with dermatomyositis (DM) and summarize the perioperative outcomes. METHODS: The clinical and pathological data of five patients diagnosed with co-occurring DM and GC (DM-GC group) were retrospectively analyzed, who were admitted to the Department of Gastrointestinal Surgery at Ren ji Hospital, Shanghai Jiao Tong University, between January 2012 and April 2023. Their data were compared with 618 GC patients (GC-1 group) from September 2016 to August 2017 and 35 GC patients who were meticulously screened from 14,580 GC cases from January 2012 and April 2023. The matching criteria included identical gender, age, tumor location, TNM stage, and surgical procedure (7 GC patients were matched for each DM-GC patient). RESULTS: Analysis indicated that the DM-GC group comprised four female and one male patient. The female proportion was significantly higher (P = 0.032) than that of GC-1 group. In DM-GC group, four DM patients were diagnosed as GC within 12 months. One DM patients was diagnosed as GC within 15 months. Among them, four patients presented with varying degrees of skin rashes, muscle weakness while one patient had elevated CK levels as the typical symptom. Similarly, the preoperative tumor markers (CA-199 and CA-125) in the DM-GC group were significantly higher than normal levels (CA-199: 100 vs. 28.6%, P = 0.002; CA-125: 40 vs. 2.9%, P = 0.003) compared to GC-2 group. Moreover, postoperative complication incidence and the length of hospital stay were significantly higher in the DM-GC than GC-2 group [complication rate: 40 vs. 8.6%, P = 0.047; hospital stay: 15 days (range: 9–28) vs. 9 days (range: 8–10), P = 0.021]. CONCLUSION: GC Patients with dermatomyositis are more prone to experience postoperative complications and longer hospital stay. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10646486/ /pubmed/38026488 http://dx.doi.org/10.3389/fsurg.2023.1276575 Text en © 2023 Aimaiti, Zhang, Aikebaier, Ni, Yin, Dong, Zhang, Guan, Bai, Wang, Xia and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Aimaiti, Muerzhate Zhang, Haoyu Aikebaier, Dilidaer Ni, Bo Yin, Hanlin Dong, Zhongyi Zhang, Yeqi Guan, Yujing Bai, Long Wang, Shuchang Xia, Xiang Zhang, Zizhen Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study |
title | Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study |
title_full | Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study |
title_fullStr | Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study |
title_full_unstemmed | Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study |
title_short | Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study |
title_sort | clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646486/ https://www.ncbi.nlm.nih.gov/pubmed/38026488 http://dx.doi.org/10.3389/fsurg.2023.1276575 |
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