Hypoxia activates SREBP2 through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth

Bone marrow‐derived cells (BMDCs) infiltrate hypoxic tumors at a pre‐angiogenic state and differentiate into mature macrophages, thereby inducing pro‐tumorigenic immunity. A critical factor regulating this differentiation is activation of SREBP2—a well‐known transcription factor participating in tum...

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Detalles Bibliográficos
Autores principales: Nakahara, Ryuichi, Aki, Sho, Sugaya, Maki, Hirose, Haruka, Kato, Miki, Maeda, Keisuke, Sakamoto, Daichi M, Kojima, Yasuhiro, Nishida, Miyuki, Ando, Ritsuko, Muramatsu, Masashi, Pan, Melvin, Tsuchida, Rika, Matsumura, Yoshihiro, Yanai, Hideyuki, Takano, Hiroshi, Yao, Ryoji, Sando, Shinsuke, Shibuya, Masabumi, Sakai, Juro, Kodama, Tatsuhiko, Kidoya, Hiroyasu, Shimamura, Teppei, Osawa, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646561/
https://www.ncbi.nlm.nih.gov/pubmed/37781951
http://dx.doi.org/10.15252/embj.2023114032

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