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The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Institute of Radiology.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646628/ https://www.ncbi.nlm.nih.gov/pubmed/37786997 http://dx.doi.org/10.1259/bjr.20230704 |
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author | Tingen, Hendrea Sanne Aletta van Praagh, Gijs D. Nienhuis, Pieter H. Tubben, Alwin van Rijsewijk, Nick D. ten Hove, Derk Mushari, Nouf A. Martinez-Lucio, T. Samara Mendoza-Ibañez, Oscar I. van Sluis, Joyce Tsoumpas, Charalampos Glaudemans, Andor W.J.M. Slart, Riemer H.J.A. |
author_facet | Tingen, Hendrea Sanne Aletta van Praagh, Gijs D. Nienhuis, Pieter H. Tubben, Alwin van Rijsewijk, Nick D. ten Hove, Derk Mushari, Nouf A. Martinez-Lucio, T. Samara Mendoza-Ibañez, Oscar I. van Sluis, Joyce Tsoumpas, Charalampos Glaudemans, Andor W.J.M. Slart, Riemer H.J.A. |
author_sort | Tingen, Hendrea Sanne Aletta |
collection | PubMed |
description | Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for this patient group and decrease CVD morbidity and mortality. Molecular imaging provides the opportunity to assess biological processes in individuals in addition to anatomical context provided by other imaging modalities and could prove to be essential in the implementation of precision medicine in CVD. New developments in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems, combined with rapid innovations in promising and specific radiopharmaceuticals, provide an impressive improvement of diagnostic accuracy and therapy evaluation. This may result in improved health outcomes in CVD patients, thereby reducing societal impact. Furthermore, recent technical advances have led to new possibilities for accurate image quantification, dynamic imaging, and quantification of radiotracer kinetics. This potentially allows for better evaluation of disease activity over time and treatment response monitoring. However, the clinical implementation of these new methods has been slow. This review describes the recent advances in molecular imaging and the clinical value of quantitative PET and SPECT in various fields in cardiovascular molecular imaging, such as atherosclerosis, myocardial perfusion and ischemia, infiltrative cardiomyopathies, systemic vascular diseases, and infectious cardiovascular diseases. Moreover, the challenges that need to be overcome to achieve clinical translation are addressed, and future directions are provided. |
format | Online Article Text |
id | pubmed-10646628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The British Institute of Radiology. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106466282023-10-24 The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine Tingen, Hendrea Sanne Aletta van Praagh, Gijs D. Nienhuis, Pieter H. Tubben, Alwin van Rijsewijk, Nick D. ten Hove, Derk Mushari, Nouf A. Martinez-Lucio, T. Samara Mendoza-Ibañez, Oscar I. van Sluis, Joyce Tsoumpas, Charalampos Glaudemans, Andor W.J.M. Slart, Riemer H.J.A. Br J Radiol Review Article Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for this patient group and decrease CVD morbidity and mortality. Molecular imaging provides the opportunity to assess biological processes in individuals in addition to anatomical context provided by other imaging modalities and could prove to be essential in the implementation of precision medicine in CVD. New developments in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems, combined with rapid innovations in promising and specific radiopharmaceuticals, provide an impressive improvement of diagnostic accuracy and therapy evaluation. This may result in improved health outcomes in CVD patients, thereby reducing societal impact. Furthermore, recent technical advances have led to new possibilities for accurate image quantification, dynamic imaging, and quantification of radiotracer kinetics. This potentially allows for better evaluation of disease activity over time and treatment response monitoring. However, the clinical implementation of these new methods has been slow. This review describes the recent advances in molecular imaging and the clinical value of quantitative PET and SPECT in various fields in cardiovascular molecular imaging, such as atherosclerosis, myocardial perfusion and ischemia, infiltrative cardiomyopathies, systemic vascular diseases, and infectious cardiovascular diseases. Moreover, the challenges that need to be overcome to achieve clinical translation are addressed, and future directions are provided. The British Institute of Radiology. 2023-11 2023-10-24 /pmc/articles/PMC10646628/ /pubmed/37786997 http://dx.doi.org/10.1259/bjr.20230704 Text en © 2023 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial reuse, provided the original author and source are credited. |
spellingShingle | Review Article Tingen, Hendrea Sanne Aletta van Praagh, Gijs D. Nienhuis, Pieter H. Tubben, Alwin van Rijsewijk, Nick D. ten Hove, Derk Mushari, Nouf A. Martinez-Lucio, T. Samara Mendoza-Ibañez, Oscar I. van Sluis, Joyce Tsoumpas, Charalampos Glaudemans, Andor W.J.M. Slart, Riemer H.J.A. The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine |
title | The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine |
title_full | The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine |
title_fullStr | The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine |
title_full_unstemmed | The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine |
title_short | The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine |
title_sort | clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646628/ https://www.ncbi.nlm.nih.gov/pubmed/37786997 http://dx.doi.org/10.1259/bjr.20230704 |
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