Cargando…

The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine

Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for t...

Descripción completa

Detalles Bibliográficos
Autores principales: Tingen, Hendrea Sanne Aletta, van Praagh, Gijs D., Nienhuis, Pieter H., Tubben, Alwin, van Rijsewijk, Nick D., ten Hove, Derk, Mushari, Nouf A., Martinez-Lucio, T. Samara, Mendoza-Ibañez, Oscar I., van Sluis, Joyce, Tsoumpas, Charalampos, Glaudemans, Andor W.J.M., Slart, Riemer H.J.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646628/
https://www.ncbi.nlm.nih.gov/pubmed/37786997
http://dx.doi.org/10.1259/bjr.20230704
_version_ 1785134931808092160
author Tingen, Hendrea Sanne Aletta
van Praagh, Gijs D.
Nienhuis, Pieter H.
Tubben, Alwin
van Rijsewijk, Nick D.
ten Hove, Derk
Mushari, Nouf A.
Martinez-Lucio, T. Samara
Mendoza-Ibañez, Oscar I.
van Sluis, Joyce
Tsoumpas, Charalampos
Glaudemans, Andor W.J.M.
Slart, Riemer H.J.A.
author_facet Tingen, Hendrea Sanne Aletta
van Praagh, Gijs D.
Nienhuis, Pieter H.
Tubben, Alwin
van Rijsewijk, Nick D.
ten Hove, Derk
Mushari, Nouf A.
Martinez-Lucio, T. Samara
Mendoza-Ibañez, Oscar I.
van Sluis, Joyce
Tsoumpas, Charalampos
Glaudemans, Andor W.J.M.
Slart, Riemer H.J.A.
author_sort Tingen, Hendrea Sanne Aletta
collection PubMed
description Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for this patient group and decrease CVD morbidity and mortality. Molecular imaging provides the opportunity to assess biological processes in individuals in addition to anatomical context provided by other imaging modalities and could prove to be essential in the implementation of precision medicine in CVD. New developments in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems, combined with rapid innovations in promising and specific radiopharmaceuticals, provide an impressive improvement of diagnostic accuracy and therapy evaluation. This may result in improved health outcomes in CVD patients, thereby reducing societal impact. Furthermore, recent technical advances have led to new possibilities for accurate image quantification, dynamic imaging, and quantification of radiotracer kinetics. This potentially allows for better evaluation of disease activity over time and treatment response monitoring. However, the clinical implementation of these new methods has been slow. This review describes the recent advances in molecular imaging and the clinical value of quantitative PET and SPECT in various fields in cardiovascular molecular imaging, such as atherosclerosis, myocardial perfusion and ischemia, infiltrative cardiomyopathies, systemic vascular diseases, and infectious cardiovascular diseases. Moreover, the challenges that need to be overcome to achieve clinical translation are addressed, and future directions are provided.
format Online
Article
Text
id pubmed-10646628
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The British Institute of Radiology.
record_format MEDLINE/PubMed
spelling pubmed-106466282023-10-24 The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine Tingen, Hendrea Sanne Aletta van Praagh, Gijs D. Nienhuis, Pieter H. Tubben, Alwin van Rijsewijk, Nick D. ten Hove, Derk Mushari, Nouf A. Martinez-Lucio, T. Samara Mendoza-Ibañez, Oscar I. van Sluis, Joyce Tsoumpas, Charalampos Glaudemans, Andor W.J.M. Slart, Riemer H.J.A. Br J Radiol Review Article Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for this patient group and decrease CVD morbidity and mortality. Molecular imaging provides the opportunity to assess biological processes in individuals in addition to anatomical context provided by other imaging modalities and could prove to be essential in the implementation of precision medicine in CVD. New developments in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems, combined with rapid innovations in promising and specific radiopharmaceuticals, provide an impressive improvement of diagnostic accuracy and therapy evaluation. This may result in improved health outcomes in CVD patients, thereby reducing societal impact. Furthermore, recent technical advances have led to new possibilities for accurate image quantification, dynamic imaging, and quantification of radiotracer kinetics. This potentially allows for better evaluation of disease activity over time and treatment response monitoring. However, the clinical implementation of these new methods has been slow. This review describes the recent advances in molecular imaging and the clinical value of quantitative PET and SPECT in various fields in cardiovascular molecular imaging, such as atherosclerosis, myocardial perfusion and ischemia, infiltrative cardiomyopathies, systemic vascular diseases, and infectious cardiovascular diseases. Moreover, the challenges that need to be overcome to achieve clinical translation are addressed, and future directions are provided. The British Institute of Radiology. 2023-11 2023-10-24 /pmc/articles/PMC10646628/ /pubmed/37786997 http://dx.doi.org/10.1259/bjr.20230704 Text en © 2023 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial reuse, provided the original author and source are credited.
spellingShingle Review Article
Tingen, Hendrea Sanne Aletta
van Praagh, Gijs D.
Nienhuis, Pieter H.
Tubben, Alwin
van Rijsewijk, Nick D.
ten Hove, Derk
Mushari, Nouf A.
Martinez-Lucio, T. Samara
Mendoza-Ibañez, Oscar I.
van Sluis, Joyce
Tsoumpas, Charalampos
Glaudemans, Andor W.J.M.
Slart, Riemer H.J.A.
The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
title The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
title_full The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
title_fullStr The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
title_full_unstemmed The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
title_short The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
title_sort clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646628/
https://www.ncbi.nlm.nih.gov/pubmed/37786997
http://dx.doi.org/10.1259/bjr.20230704
work_keys_str_mv AT tingenhendreasannealetta theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT vanpraaghgijsd theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT nienhuispieterh theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT tubbenalwin theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT vanrijsewijknickd theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT tenhovederk theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT musharinoufa theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT martinezluciotsamara theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT mendozaibanezoscari theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT vansluisjoyce theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT tsoumpascharalampos theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT glaudemansandorwjm theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT slartriemerhja theclinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT tingenhendreasannealetta clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT vanpraaghgijsd clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT nienhuispieterh clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT tubbenalwin clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT vanrijsewijknickd clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT tenhovederk clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT musharinoufa clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT martinezluciotsamara clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT mendozaibanezoscari clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT vansluisjoyce clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT tsoumpascharalampos clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT glaudemansandorwjm clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine
AT slartriemerhja clinicalvalueofquantitativecardiovascularmolecularimagingasteptowardsprecisionmedicine