Cargando…
Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
This meta-analysis aimed to compare the effectiveness of metformin versus lifestyle interventions in preventing diabetes in individuals with prediabetes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and conducted a comprehensive search of dat...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646693/ https://www.ncbi.nlm.nih.gov/pubmed/38021728 http://dx.doi.org/10.7759/cureus.47105 |
_version_ | 1785134941555654656 |
---|---|
author | Vajje, Jaahnavi Khan, Saima Kaur, Avneet Kataria, Heemali Sarpoolaki, Sahar Goudel, Aastha Bhatti, Ali Hanif Allahwala, Danish |
author_facet | Vajje, Jaahnavi Khan, Saima Kaur, Avneet Kataria, Heemali Sarpoolaki, Sahar Goudel, Aastha Bhatti, Ali Hanif Allahwala, Danish |
author_sort | Vajje, Jaahnavi |
collection | PubMed |
description | This meta-analysis aimed to compare the effectiveness of metformin versus lifestyle interventions in preventing diabetes in individuals with prediabetes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and conducted a comprehensive search of databases (PubMed, Cochrane Library, EMBASE) up to September 1, 2023. Five eligible studies were included. The results showed that there was no significant difference in the risk of developing diabetes between the metformin and lifestyle intervention groups (RR: 1.14, 95% CI: 0.77-1.68). Similarly, when comparing metformin with lifestyle intervention, the risk of diabetes was slightly higher in the metformin group, but this difference was not statistically significant (RR: 1.31, 95% CI: 0.93-1.86). When comparing metformin with lifestyle intervention to lifestyle intervention alone, no significant difference was observed in the incidence of diabetes (RR: 0.88, 95% CI: 0.74-1.04). In conclusion, our analysis found that the incidence of type 2 diabetes was slightly higher in patients receiving metformin alone compared to lifestyle intervention, but this difference did not reach statistical significance. Further trials are necessary to better evaluate these interventions for preventing type 2 diabetes in high-risk individuals. |
format | Online Article Text |
id | pubmed-10646693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-106466932023-10-16 Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials Vajje, Jaahnavi Khan, Saima Kaur, Avneet Kataria, Heemali Sarpoolaki, Sahar Goudel, Aastha Bhatti, Ali Hanif Allahwala, Danish Cureus Endocrinology/Diabetes/Metabolism This meta-analysis aimed to compare the effectiveness of metformin versus lifestyle interventions in preventing diabetes in individuals with prediabetes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and conducted a comprehensive search of databases (PubMed, Cochrane Library, EMBASE) up to September 1, 2023. Five eligible studies were included. The results showed that there was no significant difference in the risk of developing diabetes between the metformin and lifestyle intervention groups (RR: 1.14, 95% CI: 0.77-1.68). Similarly, when comparing metformin with lifestyle intervention, the risk of diabetes was slightly higher in the metformin group, but this difference was not statistically significant (RR: 1.31, 95% CI: 0.93-1.86). When comparing metformin with lifestyle intervention to lifestyle intervention alone, no significant difference was observed in the incidence of diabetes (RR: 0.88, 95% CI: 0.74-1.04). In conclusion, our analysis found that the incidence of type 2 diabetes was slightly higher in patients receiving metformin alone compared to lifestyle intervention, but this difference did not reach statistical significance. Further trials are necessary to better evaluate these interventions for preventing type 2 diabetes in high-risk individuals. Cureus 2023-10-16 /pmc/articles/PMC10646693/ /pubmed/38021728 http://dx.doi.org/10.7759/cureus.47105 Text en Copyright © 2023, Vajje et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Vajje, Jaahnavi Khan, Saima Kaur, Avneet Kataria, Heemali Sarpoolaki, Sahar Goudel, Aastha Bhatti, Ali Hanif Allahwala, Danish Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials |
title | Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials |
title_full | Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials |
title_fullStr | Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed | Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials |
title_short | Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials |
title_sort | comparison of the efficacy of metformin and lifestyle modification for the primary prevention of type 2 diabetes: a meta-analysis of randomized controlled trials |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646693/ https://www.ncbi.nlm.nih.gov/pubmed/38021728 http://dx.doi.org/10.7759/cureus.47105 |
work_keys_str_mv | AT vajjejaahnavi comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials AT khansaima comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials AT kauravneet comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials AT katariaheemali comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials AT sarpoolakisahar comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials AT goudelaastha comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials AT bhattialihanif comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials AT allahwaladanish comparisonoftheefficacyofmetforminandlifestylemodificationfortheprimarypreventionoftype2diabetesametaanalysisofrandomizedcontrolledtrials |