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Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials

This meta-analysis aimed to compare the effectiveness of metformin versus lifestyle interventions in preventing diabetes in individuals with prediabetes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and conducted a comprehensive search of dat...

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Autores principales: Vajje, Jaahnavi, Khan, Saima, Kaur, Avneet, Kataria, Heemali, Sarpoolaki, Sahar, Goudel, Aastha, Bhatti, Ali Hanif, Allahwala, Danish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646693/
https://www.ncbi.nlm.nih.gov/pubmed/38021728
http://dx.doi.org/10.7759/cureus.47105
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author Vajje, Jaahnavi
Khan, Saima
Kaur, Avneet
Kataria, Heemali
Sarpoolaki, Sahar
Goudel, Aastha
Bhatti, Ali Hanif
Allahwala, Danish
author_facet Vajje, Jaahnavi
Khan, Saima
Kaur, Avneet
Kataria, Heemali
Sarpoolaki, Sahar
Goudel, Aastha
Bhatti, Ali Hanif
Allahwala, Danish
author_sort Vajje, Jaahnavi
collection PubMed
description This meta-analysis aimed to compare the effectiveness of metformin versus lifestyle interventions in preventing diabetes in individuals with prediabetes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and conducted a comprehensive search of databases (PubMed, Cochrane Library, EMBASE) up to September 1, 2023. Five eligible studies were included. The results showed that there was no significant difference in the risk of developing diabetes between the metformin and lifestyle intervention groups (RR: 1.14, 95% CI: 0.77-1.68). Similarly, when comparing metformin with lifestyle intervention, the risk of diabetes was slightly higher in the metformin group, but this difference was not statistically significant (RR: 1.31, 95% CI: 0.93-1.86). When comparing metformin with lifestyle intervention to lifestyle intervention alone, no significant difference was observed in the incidence of diabetes (RR: 0.88, 95% CI: 0.74-1.04). In conclusion, our analysis found that the incidence of type 2 diabetes was slightly higher in patients receiving metformin alone compared to lifestyle intervention, but this difference did not reach statistical significance. Further trials are necessary to better evaluate these interventions for preventing type 2 diabetes in high-risk individuals.
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spelling pubmed-106466932023-10-16 Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials Vajje, Jaahnavi Khan, Saima Kaur, Avneet Kataria, Heemali Sarpoolaki, Sahar Goudel, Aastha Bhatti, Ali Hanif Allahwala, Danish Cureus Endocrinology/Diabetes/Metabolism This meta-analysis aimed to compare the effectiveness of metformin versus lifestyle interventions in preventing diabetes in individuals with prediabetes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and conducted a comprehensive search of databases (PubMed, Cochrane Library, EMBASE) up to September 1, 2023. Five eligible studies were included. The results showed that there was no significant difference in the risk of developing diabetes between the metformin and lifestyle intervention groups (RR: 1.14, 95% CI: 0.77-1.68). Similarly, when comparing metformin with lifestyle intervention, the risk of diabetes was slightly higher in the metformin group, but this difference was not statistically significant (RR: 1.31, 95% CI: 0.93-1.86). When comparing metformin with lifestyle intervention to lifestyle intervention alone, no significant difference was observed in the incidence of diabetes (RR: 0.88, 95% CI: 0.74-1.04). In conclusion, our analysis found that the incidence of type 2 diabetes was slightly higher in patients receiving metformin alone compared to lifestyle intervention, but this difference did not reach statistical significance. Further trials are necessary to better evaluate these interventions for preventing type 2 diabetes in high-risk individuals. Cureus 2023-10-16 /pmc/articles/PMC10646693/ /pubmed/38021728 http://dx.doi.org/10.7759/cureus.47105 Text en Copyright © 2023, Vajje et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Vajje, Jaahnavi
Khan, Saima
Kaur, Avneet
Kataria, Heemali
Sarpoolaki, Sahar
Goudel, Aastha
Bhatti, Ali Hanif
Allahwala, Danish
Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
title Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
title_full Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
title_fullStr Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
title_short Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
title_sort comparison of the efficacy of metformin and lifestyle modification for the primary prevention of type 2 diabetes: a meta-analysis of randomized controlled trials
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646693/
https://www.ncbi.nlm.nih.gov/pubmed/38021728
http://dx.doi.org/10.7759/cureus.47105
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