The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53

The NFIA-ETO2 fusion is the product of a t(1;16)(p31;q24) chromosomal translocation, so far, exclusively found in pediatric patients with pure erythroid leukemia (PEL). To address the role for the pathogenesis of the disease, we facilitated the expression of the NFIA-ETO2 fusion in murine erythrobla...

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Detalles Bibliográficos
Autores principales: Piqué-Borràs, Maria-Riera, Jevtic, Zivojin, Bagger, Frederik Otzen, Seguin, Jonathan, Sivalingam, Rathick, Bezerra, Matheus Filgueira, Louwagie, Amber, Juge, Sabine, Nellas, Ioannis, Ivanek, Robert, Tzankov, Alexandar, Moll, Ute M., Cantillo, Oriano, Schulz-Heddergott, Ramona, Fagnan, Alexandre, Mercher, Thomas, Schwaller, Juerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646783/
https://www.ncbi.nlm.nih.gov/pubmed/36735909
http://dx.doi.org/10.1182/blood.2022017273

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