Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL

Dysregulation of messenger RNA (mRNA) translation, including preferential translation of mRNA with complex 5′ untranslated regions such as the MYC oncogene, is recognized as an important mechanism in cancer. Here, we show that both human and murine chronic lymphocytic leukemia (CLL) cells display a...

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Detalles Bibliográficos
Autores principales: Largeot, Anne, Klapp, Vanessa, Viry, Elodie, Gonder, Susanne, Fernandez Botana, Iria, Blomme, Arnaud, Benzarti, Mohaned, Pierson, Sandrine, Duculty, Chloé, Marttila, Petra, Wierz, Marina, Gargiulo, Ernesto, Pagano, Giulia, An, Ning, El Hachem, Najla, Perez Hernandez, Daniel, Chakraborty, Supriya, Ysebaert, Loïc, François, Jean-Hugues, Cortez Clemente, Susan, Berchem, Guy, Efremov, Dimitar G., Dittmar, Gunnar, Szpakowska, Martyna, Chevigné, Andy, Nazarov, Petr V., Helleday, Thomas, Close, Pierre, Meiser, Johannes, Stamatopoulos, Basile, Désaubry, Laurent, Paggetti, Jérôme, Moussay, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646824/
https://www.ncbi.nlm.nih.gov/pubmed/37084385
http://dx.doi.org/10.1182/blood.2022017839

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