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National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK

BACKGROUND: The provision of neonatal care is variable and commonly lacks adequate evidence base; strategic development of methodologically robust clinical trials is needed to improve outcomes and maximise research resources. Historically, neonatal research topics have been selected by researchers;...

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Autores principales: Evans, Katie, Battersby, Cheryl, Boardman, James P, Boyle, Elaine, Carroll, Will, Dinwiddy, Kate, Dorling, Jon, Gallagher, Katie, Hardy, Pollyanna, Johnston, Emma, Mactier, Helen, Marcroft, Claire, Webbe, James William Harrison, Gale, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646876/
https://www.ncbi.nlm.nih.gov/pubmed/37094919
http://dx.doi.org/10.1136/archdischild-2023-325504
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author Evans, Katie
Battersby, Cheryl
Boardman, James P
Boyle, Elaine
Carroll, Will
Dinwiddy, Kate
Dorling, Jon
Gallagher, Katie
Hardy, Pollyanna
Johnston, Emma
Mactier, Helen
Marcroft, Claire
Webbe, James William Harrison
Gale, Chris
author_facet Evans, Katie
Battersby, Cheryl
Boardman, James P
Boyle, Elaine
Carroll, Will
Dinwiddy, Kate
Dorling, Jon
Gallagher, Katie
Hardy, Pollyanna
Johnston, Emma
Mactier, Helen
Marcroft, Claire
Webbe, James William Harrison
Gale, Chris
author_sort Evans, Katie
collection PubMed
description BACKGROUND: The provision of neonatal care is variable and commonly lacks adequate evidence base; strategic development of methodologically robust clinical trials is needed to improve outcomes and maximise research resources. Historically, neonatal research topics have been selected by researchers; prioritisation processes involving wider stakeholder groups have generally identified research themes rather than specific questions amenable to interventional trials. OBJECTIVE: To involve stakeholders including parents, healthcare professionals and researchers to identify and prioritise research questions suitable for answering in neonatal interventional trials in the UK. DESIGN: Research questions were submitted by stakeholders in population, intervention, comparison, outcome format through an online platform. Questions were reviewed by a representative steering group; duplicates and previously answered questions were removed. Eligible questions were entered into a three-round online Delphi survey for prioritisation by all stakeholder groups. PARTICIPANTS: One hundred and eight respondents submitted research questions for consideration; 144 participants completed round one of the Delphi survey, 106 completed all three rounds. RESULTS: Two hundred and sixty-five research questions were submitted and after steering group review, 186 entered into the Delphi survey. The top five ranked research questions related to breast milk fortification, intact cord resuscitation, timing of surgical intervention in necrotising enterocolitis, therapeutic hypothermia for mild hypoxic ischaemic encephalopathy and non-invasive respiratory support. CONCLUSIONS: We have identified and prioritised research questions suitable for practice-changing interventional trials in neonatal medicine in the UK at the present time. Trials targeting these uncertainties have potential to reduce research waste and improve neonatal care.
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spelling pubmed-106468762023-11-15 National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK Evans, Katie Battersby, Cheryl Boardman, James P Boyle, Elaine Carroll, Will Dinwiddy, Kate Dorling, Jon Gallagher, Katie Hardy, Pollyanna Johnston, Emma Mactier, Helen Marcroft, Claire Webbe, James William Harrison Gale, Chris Arch Dis Child Fetal Neonatal Ed Original Research BACKGROUND: The provision of neonatal care is variable and commonly lacks adequate evidence base; strategic development of methodologically robust clinical trials is needed to improve outcomes and maximise research resources. Historically, neonatal research topics have been selected by researchers; prioritisation processes involving wider stakeholder groups have generally identified research themes rather than specific questions amenable to interventional trials. OBJECTIVE: To involve stakeholders including parents, healthcare professionals and researchers to identify and prioritise research questions suitable for answering in neonatal interventional trials in the UK. DESIGN: Research questions were submitted by stakeholders in population, intervention, comparison, outcome format through an online platform. Questions were reviewed by a representative steering group; duplicates and previously answered questions were removed. Eligible questions were entered into a three-round online Delphi survey for prioritisation by all stakeholder groups. PARTICIPANTS: One hundred and eight respondents submitted research questions for consideration; 144 participants completed round one of the Delphi survey, 106 completed all three rounds. RESULTS: Two hundred and sixty-five research questions were submitted and after steering group review, 186 entered into the Delphi survey. The top five ranked research questions related to breast milk fortification, intact cord resuscitation, timing of surgical intervention in necrotising enterocolitis, therapeutic hypothermia for mild hypoxic ischaemic encephalopathy and non-invasive respiratory support. CONCLUSIONS: We have identified and prioritised research questions suitable for practice-changing interventional trials in neonatal medicine in the UK at the present time. Trials targeting these uncertainties have potential to reduce research waste and improve neonatal care. BMJ Publishing Group 2023-11 2023-04-24 /pmc/articles/PMC10646876/ /pubmed/37094919 http://dx.doi.org/10.1136/archdischild-2023-325504 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Research
Evans, Katie
Battersby, Cheryl
Boardman, James P
Boyle, Elaine
Carroll, Will
Dinwiddy, Kate
Dorling, Jon
Gallagher, Katie
Hardy, Pollyanna
Johnston, Emma
Mactier, Helen
Marcroft, Claire
Webbe, James William Harrison
Gale, Chris
National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK
title National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK
title_full National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK
title_fullStr National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK
title_full_unstemmed National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK
title_short National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK
title_sort national priority setting partnership using a delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the uk
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646876/
https://www.ncbi.nlm.nih.gov/pubmed/37094919
http://dx.doi.org/10.1136/archdischild-2023-325504
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