Discovery of a selective TC-PTP degrader for cancer immunotherapy

T-cell protein tyrosine phosphatase (TC-PTP), encoded by PTPN2, has emerged as a promising target for cancer immunotherapy. TC-PTP deletion in B16 melanoma cells promotes tumor cell antigen presentation, while loss of TC-PTP in T-cells enhances T-cell receptor (TCR) signaling and stimulates cell pro...

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Detalles Bibliográficos
Autores principales: Miao, Jinmin, Dong, Jiajun, Miao, Yiming, Bai, Yunpeng, Qu, Zihan, Jassim, Brenson A., Huang, Bo, Nguyen, Quyen, Ma, Yuan, Murray, Allison A., Li, Jinyue, Low, Philip S., Zhang, Zhong-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646932/
https://www.ncbi.nlm.nih.gov/pubmed/38020389
http://dx.doi.org/10.1039/d3sc04541b

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