Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

[Image: see text] Galectins, the glycan binding proteins, and their respective carbohydrate ligands represent a unique fundamental regulatory network modulating a plethora of biological processes. The advances in galectin-targeted therapy must be based on a deep understanding of the mechanism of lig...

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Detalles Bibliográficos
Autores principales: Müllerová, Monika, Hovorková, Michaela, Závodná, Táňa, Červenková Št́astná, Lucie, Krupková, Alena, Hamala, Vojtěch, Nováková, Kateřina, Topinka, Jan, Bojarová, Pavla, Strašák, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646984/
https://www.ncbi.nlm.nih.gov/pubmed/37680126
http://dx.doi.org/10.1021/acs.biomac.3c00426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646984/
https://www.ncbi.nlm.nih.gov/pubmed/37680126
http://dx.doi.org/10.1021/acs.biomac.3c00426

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