T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy

Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We...

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Detalles Bibliográficos
Autores principales: Denis, Colin, Dabbs, Kevin, Nair, Veena A., Mathis, Jedidiah, Almane, Dace N., Lakshmanan, Akshayaa, Nencka, Andrew, Birn, Rasmus M., Conant, Lisa, Humphries, Colin, Felton, Elizabeth, Raghavan, Manoj, DeYoe, Edgar A., Binder, Jeffrey R., Hermann, Bruce, Prabhakaran, Vivek, Bendlin, Barbara B., Meyerand, Mary E., Boly, Mélanie, Struck, Aaron F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647008/
https://www.ncbi.nlm.nih.gov/pubmed/37872734
http://dx.doi.org/10.1002/acn3.51653
Descripción
Sumario:Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age‐matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group‐level aberrations in overall myelin content or myelin changes through time in TLE.

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