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Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein

BACKGROUND: Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein aggregates and brain immune activation have triggering roles in synaptic failure but the neuronal mechanisms underlying synapse loss are unclear. On the neu...

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Detalles Bibliográficos
Autores principales:	Stoner, Austin, Fu, Li, Nicholson, LaShae, Zheng, Chao, Toyonaga, Takuya, Spurrier, Joshua, Laird, Will, Cai, Zhengxin, Strittmatter, Stephen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647125/ https://www.ncbi.nlm.nih.gov/pubmed/37968719 http://dx.doi.org/10.1186/s13195-023-01345-z

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