Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin

BACKGROUND: As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ, potently modify the behavior of healthy stromal cells. A subpopulation of cancer-associated fibroblasts expressing a TGFβ...

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Detalles Bibliográficos
Autores principales: Franco-Valls, Héctor, Tusquets-Uxó, Elsa, Sala, Laura, Val, Maria, Peña, Raúl, Iaconcig, Alessandra, Villarino, Álvaro, Jiménez-Arriola, Martín, Massó, Pere, Trincado, Juan L., Eyras, Eduardo, Muro, Andrés F., Otero, Jorge, García de Herreros, Antonio, Baulida, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647173/
https://www.ncbi.nlm.nih.gov/pubmed/37964360
http://dx.doi.org/10.1186/s13058-023-01736-y

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