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Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647240/ https://www.ncbi.nlm.nih.gov/pubmed/37958896 http://dx.doi.org/10.3390/ijms242115908 |
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author | Li, Siyu Li, Jun Cheng, Wei He, Wenhui Dai, Shuang-Shuang |
author_facet | Li, Siyu Li, Jun Cheng, Wei He, Wenhui Dai, Shuang-Shuang |
author_sort | Li, Siyu |
collection | PubMed |
description | Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune cell infiltration in the media and adventitia of the aorta is a novel hallmark of AD. These cells contribute to changes in the immune microenvironment, which can affect their own metabolism and that of parenchymal cells in the aortic wall, which are essential factors that induce degeneration and remodeling of the vascular wall and play important roles in the formation and development of AD. Accordingly, this review focuses on the independent and interactive roles of immunity and metabolism in AD to provide further insights into the pathogenesis, novel ideas for diagnosis and new strategies for treatment or early prevention of AD. |
format | Online Article Text |
id | pubmed-10647240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106472402023-11-02 Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection Li, Siyu Li, Jun Cheng, Wei He, Wenhui Dai, Shuang-Shuang Int J Mol Sci Review Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune cell infiltration in the media and adventitia of the aorta is a novel hallmark of AD. These cells contribute to changes in the immune microenvironment, which can affect their own metabolism and that of parenchymal cells in the aortic wall, which are essential factors that induce degeneration and remodeling of the vascular wall and play important roles in the formation and development of AD. Accordingly, this review focuses on the independent and interactive roles of immunity and metabolism in AD to provide further insights into the pathogenesis, novel ideas for diagnosis and new strategies for treatment or early prevention of AD. MDPI 2023-11-02 /pmc/articles/PMC10647240/ /pubmed/37958896 http://dx.doi.org/10.3390/ijms242115908 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Siyu Li, Jun Cheng, Wei He, Wenhui Dai, Shuang-Shuang Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
title | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
title_full | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
title_fullStr | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
title_full_unstemmed | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
title_short | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
title_sort | independent and interactive roles of immunity and metabolism in aortic dissection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647240/ https://www.ncbi.nlm.nih.gov/pubmed/37958896 http://dx.doi.org/10.3390/ijms242115908 |
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