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Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection

Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune...

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Autores principales: Li, Siyu, Li, Jun, Cheng, Wei, He, Wenhui, Dai, Shuang-Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647240/
https://www.ncbi.nlm.nih.gov/pubmed/37958896
http://dx.doi.org/10.3390/ijms242115908
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author Li, Siyu
Li, Jun
Cheng, Wei
He, Wenhui
Dai, Shuang-Shuang
author_facet Li, Siyu
Li, Jun
Cheng, Wei
He, Wenhui
Dai, Shuang-Shuang
author_sort Li, Siyu
collection PubMed
description Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune cell infiltration in the media and adventitia of the aorta is a novel hallmark of AD. These cells contribute to changes in the immune microenvironment, which can affect their own metabolism and that of parenchymal cells in the aortic wall, which are essential factors that induce degeneration and remodeling of the vascular wall and play important roles in the formation and development of AD. Accordingly, this review focuses on the independent and interactive roles of immunity and metabolism in AD to provide further insights into the pathogenesis, novel ideas for diagnosis and new strategies for treatment or early prevention of AD.
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spelling pubmed-106472402023-11-02 Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection Li, Siyu Li, Jun Cheng, Wei He, Wenhui Dai, Shuang-Shuang Int J Mol Sci Review Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune cell infiltration in the media and adventitia of the aorta is a novel hallmark of AD. These cells contribute to changes in the immune microenvironment, which can affect their own metabolism and that of parenchymal cells in the aortic wall, which are essential factors that induce degeneration and remodeling of the vascular wall and play important roles in the formation and development of AD. Accordingly, this review focuses on the independent and interactive roles of immunity and metabolism in AD to provide further insights into the pathogenesis, novel ideas for diagnosis and new strategies for treatment or early prevention of AD. MDPI 2023-11-02 /pmc/articles/PMC10647240/ /pubmed/37958896 http://dx.doi.org/10.3390/ijms242115908 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Siyu
Li, Jun
Cheng, Wei
He, Wenhui
Dai, Shuang-Shuang
Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
title Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
title_full Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
title_fullStr Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
title_full_unstemmed Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
title_short Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
title_sort independent and interactive roles of immunity and metabolism in aortic dissection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647240/
https://www.ncbi.nlm.nih.gov/pubmed/37958896
http://dx.doi.org/10.3390/ijms242115908
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