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Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization

This review article dives into the complex world of biocompatibility testing: chemical, mechanical, and biological characterization, including many elements of biocompatibility, such as definitions, descriptive examples, and the practical settings. The focus extends to evaluating standard documents...

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Autores principales: Al-Zyoud, Walid, Haddadin, Dana, Hasan, Sameer Ahmad, Jaradat, Hussamaldeen, Kanoun, Olfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647244/
https://www.ncbi.nlm.nih.gov/pubmed/37959478
http://dx.doi.org/10.3390/ma16216881
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author Al-Zyoud, Walid
Haddadin, Dana
Hasan, Sameer Ahmad
Jaradat, Hussamaldeen
Kanoun, Olfa
author_facet Al-Zyoud, Walid
Haddadin, Dana
Hasan, Sameer Ahmad
Jaradat, Hussamaldeen
Kanoun, Olfa
author_sort Al-Zyoud, Walid
collection PubMed
description This review article dives into the complex world of biocompatibility testing: chemical, mechanical, and biological characterization, including many elements of biocompatibility, such as definitions, descriptive examples, and the practical settings. The focus extends to evaluating standard documents obtained from reliable organizations; with a particular focus on open-source information, including FDA-USA, ISO 10933 series, and TÜV SÜD. We found a significant gap in this field: biomaterial scientists and those involved in the realm of medical device development in general, and implants in particular, lack access to a tool that reorganizes the process of selecting the appropriate biocompatibility test for the implant being examined. This work progressed through two key phases that aimed to provide a solution to this gap. A straightforward “yes or no” flowchart was initially developed to guide biocompatibility testing decisions based on the previously accumulated information. Subsequently, the Python code was employed, generating a framework through targeted questions. This work reshapes biocompatibility evaluation, bridging theory and practical implementation. An integrated approach via a flowchart and the Python code empowers stakeholders to navigate biocompatibility testing effortlessly. To conclude, researchers are now better equipped for a safer, more effective implant development, propelling the field towards improved patient care and innovative progress.
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spelling pubmed-106472442023-10-26 Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization Al-Zyoud, Walid Haddadin, Dana Hasan, Sameer Ahmad Jaradat, Hussamaldeen Kanoun, Olfa Materials (Basel) Review This review article dives into the complex world of biocompatibility testing: chemical, mechanical, and biological characterization, including many elements of biocompatibility, such as definitions, descriptive examples, and the practical settings. The focus extends to evaluating standard documents obtained from reliable organizations; with a particular focus on open-source information, including FDA-USA, ISO 10933 series, and TÜV SÜD. We found a significant gap in this field: biomaterial scientists and those involved in the realm of medical device development in general, and implants in particular, lack access to a tool that reorganizes the process of selecting the appropriate biocompatibility test for the implant being examined. This work progressed through two key phases that aimed to provide a solution to this gap. A straightforward “yes or no” flowchart was initially developed to guide biocompatibility testing decisions based on the previously accumulated information. Subsequently, the Python code was employed, generating a framework through targeted questions. This work reshapes biocompatibility evaluation, bridging theory and practical implementation. An integrated approach via a flowchart and the Python code empowers stakeholders to navigate biocompatibility testing effortlessly. To conclude, researchers are now better equipped for a safer, more effective implant development, propelling the field towards improved patient care and innovative progress. MDPI 2023-10-26 /pmc/articles/PMC10647244/ /pubmed/37959478 http://dx.doi.org/10.3390/ma16216881 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Al-Zyoud, Walid
Haddadin, Dana
Hasan, Sameer Ahmad
Jaradat, Hussamaldeen
Kanoun, Olfa
Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization
title Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization
title_full Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization
title_fullStr Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization
title_full_unstemmed Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization
title_short Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization
title_sort biocompatibility testing for implants: a novel tool for selection and characterization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647244/
https://www.ncbi.nlm.nih.gov/pubmed/37959478
http://dx.doi.org/10.3390/ma16216881
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