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Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II)
Ligustrum robustum has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of L. robustum, ten new monoterpenoid glycosides named ligurobustosides T(10) (1a), T(11) (...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647328/ https://www.ncbi.nlm.nih.gov/pubmed/37959693 http://dx.doi.org/10.3390/molecules28217274 |
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author | Lu, Shi-Hui Li, Xiu-Xia Zuo, Hao-Jiang Li, Wei-Neng Pan, Jia-Ping Huang, Jing |
author_facet | Lu, Shi-Hui Li, Xiu-Xia Zuo, Hao-Jiang Li, Wei-Neng Pan, Jia-Ping Huang, Jing |
author_sort | Lu, Shi-Hui |
collection | PubMed |
description | Ligustrum robustum has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of L. robustum, ten new monoterpenoid glycosides named ligurobustosides T(10) (1a), T(11) (1b), T(12) (2a), T(13) (2b), T(14) (3a), T(15) (3b), F(1) (4b), T(16) (5a), T(17) (5b), and E(1) (6b), together with five known ones (4a, 6a, 7, 8a, 8b), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound 5 (IC(50): 4.38 ± 0.11 μM) was as strong as orlistat (IC(50): 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds 1–4 and 7–8, and the α-amylase inhibitory actions of compounds 1–8 were medium; the ABTS radical scavenging capacities of compounds 1–3 and 5–8 (IC(50): 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than l-(+)-ascorbic acid (IC(50): 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of L. robustum to prevent diabetes and its complications. |
format | Online Article Text |
id | pubmed-10647328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106473282023-10-26 Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II) Lu, Shi-Hui Li, Xiu-Xia Zuo, Hao-Jiang Li, Wei-Neng Pan, Jia-Ping Huang, Jing Molecules Article Ligustrum robustum has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of L. robustum, ten new monoterpenoid glycosides named ligurobustosides T(10) (1a), T(11) (1b), T(12) (2a), T(13) (2b), T(14) (3a), T(15) (3b), F(1) (4b), T(16) (5a), T(17) (5b), and E(1) (6b), together with five known ones (4a, 6a, 7, 8a, 8b), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound 5 (IC(50): 4.38 ± 0.11 μM) was as strong as orlistat (IC(50): 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds 1–4 and 7–8, and the α-amylase inhibitory actions of compounds 1–8 were medium; the ABTS radical scavenging capacities of compounds 1–3 and 5–8 (IC(50): 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than l-(+)-ascorbic acid (IC(50): 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of L. robustum to prevent diabetes and its complications. MDPI 2023-10-26 /pmc/articles/PMC10647328/ /pubmed/37959693 http://dx.doi.org/10.3390/molecules28217274 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lu, Shi-Hui Li, Xiu-Xia Zuo, Hao-Jiang Li, Wei-Neng Pan, Jia-Ping Huang, Jing Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II) |
title | Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II) |
title_full | Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II) |
title_fullStr | Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II) |
title_full_unstemmed | Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II) |
title_short | Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II) |
title_sort | monoterpenoid glycosides from the leaves of ligustrum robustum and their bioactivities (ii) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647328/ https://www.ncbi.nlm.nih.gov/pubmed/37959693 http://dx.doi.org/10.3390/molecules28217274 |
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