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Occupational Etiology of Oropharyngeal Cancer: A Literature Review

While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of...

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Autores principales: Nikkilä, Rayan, Tolonen, Suvi, Salo, Tuula, Carpén, Timo, Pukkala, Eero, Mäkitie, Antti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647348/
https://www.ncbi.nlm.nih.gov/pubmed/37947576
http://dx.doi.org/10.3390/ijerph20217020
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author Nikkilä, Rayan
Tolonen, Suvi
Salo, Tuula
Carpén, Timo
Pukkala, Eero
Mäkitie, Antti
author_facet Nikkilä, Rayan
Tolonen, Suvi
Salo, Tuula
Carpén, Timo
Pukkala, Eero
Mäkitie, Antti
author_sort Nikkilä, Rayan
collection PubMed
description While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose–response analyses adequately adjusted for confounders.
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spelling pubmed-106473482023-11-03 Occupational Etiology of Oropharyngeal Cancer: A Literature Review Nikkilä, Rayan Tolonen, Suvi Salo, Tuula Carpén, Timo Pukkala, Eero Mäkitie, Antti Int J Environ Res Public Health Review While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose–response analyses adequately adjusted for confounders. MDPI 2023-11-03 /pmc/articles/PMC10647348/ /pubmed/37947576 http://dx.doi.org/10.3390/ijerph20217020 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nikkilä, Rayan
Tolonen, Suvi
Salo, Tuula
Carpén, Timo
Pukkala, Eero
Mäkitie, Antti
Occupational Etiology of Oropharyngeal Cancer: A Literature Review
title Occupational Etiology of Oropharyngeal Cancer: A Literature Review
title_full Occupational Etiology of Oropharyngeal Cancer: A Literature Review
title_fullStr Occupational Etiology of Oropharyngeal Cancer: A Literature Review
title_full_unstemmed Occupational Etiology of Oropharyngeal Cancer: A Literature Review
title_short Occupational Etiology of Oropharyngeal Cancer: A Literature Review
title_sort occupational etiology of oropharyngeal cancer: a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647348/
https://www.ncbi.nlm.nih.gov/pubmed/37947576
http://dx.doi.org/10.3390/ijerph20217020
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