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Occupational Etiology of Oropharyngeal Cancer: A Literature Review
While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647348/ https://www.ncbi.nlm.nih.gov/pubmed/37947576 http://dx.doi.org/10.3390/ijerph20217020 |
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author | Nikkilä, Rayan Tolonen, Suvi Salo, Tuula Carpén, Timo Pukkala, Eero Mäkitie, Antti |
author_facet | Nikkilä, Rayan Tolonen, Suvi Salo, Tuula Carpén, Timo Pukkala, Eero Mäkitie, Antti |
author_sort | Nikkilä, Rayan |
collection | PubMed |
description | While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose–response analyses adequately adjusted for confounders. |
format | Online Article Text |
id | pubmed-10647348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106473482023-11-03 Occupational Etiology of Oropharyngeal Cancer: A Literature Review Nikkilä, Rayan Tolonen, Suvi Salo, Tuula Carpén, Timo Pukkala, Eero Mäkitie, Antti Int J Environ Res Public Health Review While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose–response analyses adequately adjusted for confounders. MDPI 2023-11-03 /pmc/articles/PMC10647348/ /pubmed/37947576 http://dx.doi.org/10.3390/ijerph20217020 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nikkilä, Rayan Tolonen, Suvi Salo, Tuula Carpén, Timo Pukkala, Eero Mäkitie, Antti Occupational Etiology of Oropharyngeal Cancer: A Literature Review |
title | Occupational Etiology of Oropharyngeal Cancer: A Literature Review |
title_full | Occupational Etiology of Oropharyngeal Cancer: A Literature Review |
title_fullStr | Occupational Etiology of Oropharyngeal Cancer: A Literature Review |
title_full_unstemmed | Occupational Etiology of Oropharyngeal Cancer: A Literature Review |
title_short | Occupational Etiology of Oropharyngeal Cancer: A Literature Review |
title_sort | occupational etiology of oropharyngeal cancer: a literature review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647348/ https://www.ncbi.nlm.nih.gov/pubmed/37947576 http://dx.doi.org/10.3390/ijerph20217020 |
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