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Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis

Breast cancer (BC) is the most diagnosed cancer in women and the second most common cancer globally. Significant advances in BC research have led to improved early detection and effective therapies. One of the key challenges in BC is the presence of BC stem cells (BCSCs). This small subpopulation wi...

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Autores principales: Nogueras Pérez, Raquel, Heredia-Nicolás, Noelia, de Lara-Peña, Laura, López de Andrés, Julia, Marchal, Juan Antonio, Jiménez, Gema, Griñán-Lisón, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647353/
https://www.ncbi.nlm.nih.gov/pubmed/37958993
http://dx.doi.org/10.3390/ijms242116010
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author Nogueras Pérez, Raquel
Heredia-Nicolás, Noelia
de Lara-Peña, Laura
López de Andrés, Julia
Marchal, Juan Antonio
Jiménez, Gema
Griñán-Lisón, Carmen
author_facet Nogueras Pérez, Raquel
Heredia-Nicolás, Noelia
de Lara-Peña, Laura
López de Andrés, Julia
Marchal, Juan Antonio
Jiménez, Gema
Griñán-Lisón, Carmen
author_sort Nogueras Pérez, Raquel
collection PubMed
description Breast cancer (BC) is the most diagnosed cancer in women and the second most common cancer globally. Significant advances in BC research have led to improved early detection and effective therapies. One of the key challenges in BC is the presence of BC stem cells (BCSCs). This small subpopulation within the tumor possesses unique characteristics, including tumor-initiating capabilities, contributes to treatment resistance, and plays a role in cancer recurrence and metastasis. In recent years, microRNAs (miRNAs) have emerged as potential regulators of BCSCs, which can modulate gene expression and influence cellular processes like BCSCs’ self-renewal, differentiation, and tumor-promoting pathways. Understanding the miRNA signatures of BCSCs holds great promise for improving BC diagnosis and prognosis. By targeting BCSCs and their associated miRNAs, researchers aim to develop more effective and personalized treatment strategies that may offer better outcomes for BC patients, minimizing tumor recurrence and metastasis. In conclusion, the investigation of miRNAs as regulators of BCSCs opens new directions for advancing BC research through the use of bioinformatics and the development of innovative therapeutic approaches. This review summarizes the most recent and innovative studies and clinical trials on the role of BCSCs miRNAs as potential tools for early diagnosis, prognosis, and resistance.
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spelling pubmed-106473532023-11-06 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis Nogueras Pérez, Raquel Heredia-Nicolás, Noelia de Lara-Peña, Laura López de Andrés, Julia Marchal, Juan Antonio Jiménez, Gema Griñán-Lisón, Carmen Int J Mol Sci Review Breast cancer (BC) is the most diagnosed cancer in women and the second most common cancer globally. Significant advances in BC research have led to improved early detection and effective therapies. One of the key challenges in BC is the presence of BC stem cells (BCSCs). This small subpopulation within the tumor possesses unique characteristics, including tumor-initiating capabilities, contributes to treatment resistance, and plays a role in cancer recurrence and metastasis. In recent years, microRNAs (miRNAs) have emerged as potential regulators of BCSCs, which can modulate gene expression and influence cellular processes like BCSCs’ self-renewal, differentiation, and tumor-promoting pathways. Understanding the miRNA signatures of BCSCs holds great promise for improving BC diagnosis and prognosis. By targeting BCSCs and their associated miRNAs, researchers aim to develop more effective and personalized treatment strategies that may offer better outcomes for BC patients, minimizing tumor recurrence and metastasis. In conclusion, the investigation of miRNAs as regulators of BCSCs opens new directions for advancing BC research through the use of bioinformatics and the development of innovative therapeutic approaches. This review summarizes the most recent and innovative studies and clinical trials on the role of BCSCs miRNAs as potential tools for early diagnosis, prognosis, and resistance. MDPI 2023-11-06 /pmc/articles/PMC10647353/ /pubmed/37958993 http://dx.doi.org/10.3390/ijms242116010 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nogueras Pérez, Raquel
Heredia-Nicolás, Noelia
de Lara-Peña, Laura
López de Andrés, Julia
Marchal, Juan Antonio
Jiménez, Gema
Griñán-Lisón, Carmen
Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis
title Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis
title_full Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis
title_fullStr Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis
title_full_unstemmed Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis
title_short Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis
title_sort unraveling the potential of mirnas from cscs as an emerging clinical tool for breast cancer diagnosis and prognosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647353/
https://www.ncbi.nlm.nih.gov/pubmed/37958993
http://dx.doi.org/10.3390/ijms242116010
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