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HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk

Associations of HLA class II alleles with genital chlamydial infection outcomes have been reported, especially HLA DQB1*06. However, the potential role of DQB1*06 in influencing reinfection risk has still not been established. The purpose of this study was to determine whether the association of DQB...

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Autores principales: Gupta, Kanupriya, Wiener, Howard W., Tiwari, Hemant K., Geisler, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647357/
https://www.ncbi.nlm.nih.gov/pubmed/37958786
http://dx.doi.org/10.3390/ijms242115803
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author Gupta, Kanupriya
Wiener, Howard W.
Tiwari, Hemant K.
Geisler, William M.
author_facet Gupta, Kanupriya
Wiener, Howard W.
Tiwari, Hemant K.
Geisler, William M.
author_sort Gupta, Kanupriya
collection PubMed
description Associations of HLA class II alleles with genital chlamydial infection outcomes have been reported, especially HLA DQB1*06. However, the potential role of DQB1*06 in influencing reinfection risk has still not been established. The purpose of this study was to determine whether the association of DQB1*06 with chlamydia reinfection was impacted by any other nearby HLA class II variants that were also associated with reinfection. We used next-generation sequencing to map HLA class II variants spanning the HLA-DQ and -DR loci. DQB1*06 as well as DQB1*04 were confirmed as significant predictors of chlamydia reinfection, when controlling for age and percent African ancestry. SKAT analysis revealed one region each in DRB1, DRB5, DQA2, and three intergenic regions that had variants associated with reinfection. Further analyses of these variants revealed that rs112651494 within DRB5 and an intergenic SNP rs617058 in DRB1:DQA1 were significantly associated with reinfection, but this did not impact the significance of the association of DQB1*06 or DQB1*04 with reinfection.
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spelling pubmed-106473572023-10-31 HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk Gupta, Kanupriya Wiener, Howard W. Tiwari, Hemant K. Geisler, William M. Int J Mol Sci Article Associations of HLA class II alleles with genital chlamydial infection outcomes have been reported, especially HLA DQB1*06. However, the potential role of DQB1*06 in influencing reinfection risk has still not been established. The purpose of this study was to determine whether the association of DQB1*06 with chlamydia reinfection was impacted by any other nearby HLA class II variants that were also associated with reinfection. We used next-generation sequencing to map HLA class II variants spanning the HLA-DQ and -DR loci. DQB1*06 as well as DQB1*04 were confirmed as significant predictors of chlamydia reinfection, when controlling for age and percent African ancestry. SKAT analysis revealed one region each in DRB1, DRB5, DQA2, and three intergenic regions that had variants associated with reinfection. Further analyses of these variants revealed that rs112651494 within DRB5 and an intergenic SNP rs617058 in DRB1:DQA1 were significantly associated with reinfection, but this did not impact the significance of the association of DQB1*06 or DQB1*04 with reinfection. MDPI 2023-10-31 /pmc/articles/PMC10647357/ /pubmed/37958786 http://dx.doi.org/10.3390/ijms242115803 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gupta, Kanupriya
Wiener, Howard W.
Tiwari, Hemant K.
Geisler, William M.
HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk
title HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk
title_full HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk
title_fullStr HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk
title_full_unstemmed HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk
title_short HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk
title_sort hla-dqb1*06 and select neighboring hla variants predict chlamydia reinfection risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647357/
https://www.ncbi.nlm.nih.gov/pubmed/37958786
http://dx.doi.org/10.3390/ijms242115803
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