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Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study

Lipoprotein(a) (Lp(a)) is considered an independent risk factor for cardiovascular diseases. The plasma concentration of Lp(a) is largely genetically determined but varies over a wide range within the population. This study investigated changes in Lp(a) levels after an acute myocardial infarction. P...

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Autores principales: Sourij, Caren, Aziz, Faisal, Krappinger, Sarah, Praschk, Andreas, Metzner, Thomas, Kojzar, Harald, Zirlik, Andreas, Stojakovic, Tatjana, Pätzold, Dieter, von Lewinski, Dirk, Zweiker, Robert, Scharnagl, Hubert, Sourij, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647358/
https://www.ncbi.nlm.nih.gov/pubmed/37958516
http://dx.doi.org/10.3390/ijms242115531
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author Sourij, Caren
Aziz, Faisal
Krappinger, Sarah
Praschk, Andreas
Metzner, Thomas
Kojzar, Harald
Zirlik, Andreas
Stojakovic, Tatjana
Pätzold, Dieter
von Lewinski, Dirk
Zweiker, Robert
Scharnagl, Hubert
Sourij, Harald
author_facet Sourij, Caren
Aziz, Faisal
Krappinger, Sarah
Praschk, Andreas
Metzner, Thomas
Kojzar, Harald
Zirlik, Andreas
Stojakovic, Tatjana
Pätzold, Dieter
von Lewinski, Dirk
Zweiker, Robert
Scharnagl, Hubert
Sourij, Harald
author_sort Sourij, Caren
collection PubMed
description Lipoprotein(a) (Lp(a)) is considered an independent risk factor for cardiovascular diseases. The plasma concentration of Lp(a) is largely genetically determined but varies over a wide range within the population. This study investigated changes in Lp(a) levels after an acute myocardial infarction. Patients who underwent coronary angiography due to an ST elevation myocardial infarction were enrolled (n = 86), and Lp(a) levels were measured immediately after the intervention, one day, two days, and at a post-discharge follow-up visit at 3 to 6 months after the acute myocardial infarction. Median Lp(a) levels increased from a median of 7.9 mg/dL (3.8–37.1) at hospital admission to 8.4 mg/dL (3.9–35.4) on the following day, then to 9.3 mg/dL (3.7–39.1) on day two (p < 0.001), and to 11.2 mg/dL (4.4–59.6) at the post-discharge follow-up (p < 0.001). Lp(a) levels were the lowest during the acute myocardial infarction and started to increase significantly immediately thereafter, with the highest levels at the post-discharge follow-up. The moderate but significant increase in Lp(a) in people with acute myocardial infarction appears to be clinically relevant on an individual basis, especially when specific Lp(a) cut-off levels are supposed to determine the initiation of future treatment. Hence, a repeated measurement of Lp(a) after myocardial infarction should be performed.
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spelling pubmed-106473582023-10-24 Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study Sourij, Caren Aziz, Faisal Krappinger, Sarah Praschk, Andreas Metzner, Thomas Kojzar, Harald Zirlik, Andreas Stojakovic, Tatjana Pätzold, Dieter von Lewinski, Dirk Zweiker, Robert Scharnagl, Hubert Sourij, Harald Int J Mol Sci Communication Lipoprotein(a) (Lp(a)) is considered an independent risk factor for cardiovascular diseases. The plasma concentration of Lp(a) is largely genetically determined but varies over a wide range within the population. This study investigated changes in Lp(a) levels after an acute myocardial infarction. Patients who underwent coronary angiography due to an ST elevation myocardial infarction were enrolled (n = 86), and Lp(a) levels were measured immediately after the intervention, one day, two days, and at a post-discharge follow-up visit at 3 to 6 months after the acute myocardial infarction. Median Lp(a) levels increased from a median of 7.9 mg/dL (3.8–37.1) at hospital admission to 8.4 mg/dL (3.9–35.4) on the following day, then to 9.3 mg/dL (3.7–39.1) on day two (p < 0.001), and to 11.2 mg/dL (4.4–59.6) at the post-discharge follow-up (p < 0.001). Lp(a) levels were the lowest during the acute myocardial infarction and started to increase significantly immediately thereafter, with the highest levels at the post-discharge follow-up. The moderate but significant increase in Lp(a) in people with acute myocardial infarction appears to be clinically relevant on an individual basis, especially when specific Lp(a) cut-off levels are supposed to determine the initiation of future treatment. Hence, a repeated measurement of Lp(a) after myocardial infarction should be performed. MDPI 2023-10-24 /pmc/articles/PMC10647358/ /pubmed/37958516 http://dx.doi.org/10.3390/ijms242115531 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Sourij, Caren
Aziz, Faisal
Krappinger, Sarah
Praschk, Andreas
Metzner, Thomas
Kojzar, Harald
Zirlik, Andreas
Stojakovic, Tatjana
Pätzold, Dieter
von Lewinski, Dirk
Zweiker, Robert
Scharnagl, Hubert
Sourij, Harald
Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study
title Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study
title_full Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study
title_fullStr Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study
title_full_unstemmed Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study
title_short Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction—The STEMI-Lipids Study
title_sort changes in lipoprotein(a) levels in people after st elevation myocardial infarction—the stemi-lipids study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647358/
https://www.ncbi.nlm.nih.gov/pubmed/37958516
http://dx.doi.org/10.3390/ijms242115531
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